Evidence map›Paper›PMID 36679953›Full record

ArticleVaccines2023

Outcomes of Extracorporeal Membrane Oxygenation (ECMO) for COVID-19 Patients: A Multi-Institutional Analysis.

Maged Makhoul, Eitan Keizman, Uri Carmi, Ori Galante, Eduard Ilgiyaev, Moshe Matan, Artur Słomka, Sigal Sviri, Arieh Eden, Arie Soroksky and 5 more

Abstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maged MakhoulDepartment of Cardiac Surgery, Rambam Medical Center, Haifa 3525408, Israel.ORCID 0000-0002-4487-1153
Eitan KeizmanDepartment of Cardiac Surgery, The Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0002-0961-8777
Uri CarmiDivision of Anesthesia, Pain and Intensive Care, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
Ori GalanteMedical Intensive Care Unit, Faculty of Health Ben Gurion University, Soroka Medical Center, Beer-Sheva 8400711, Israel.ORCID 0000-0001-9977-1304
Eduard IlgiyaevIntensive Care Unit, Shamir Medical Center, Zerifin 703301, Israel.
Moshe MatanIntensive Care Unit, The Baruch Padeh Medical Center, Poriya 1528001, Israel.
Artur SłomkaDepartment of Pathophysiology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier CollegiumMedicum, 85-094 Bydgoszcz, Poland.ORCID 0000-0002-4137-2981
Sigal SviriMedical Intensive Care, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Arieh EdenDepartment of Anesthesiology Critical Care and Pain Medicine, Carmel Lady Davis Medical Center, Haifa 3436212, Israel.ORCID 0000-0001-6217-9630
Arie SorokskyIntensive Care Unit, E. Wolfson Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0002-3331-6963
Danny FinkIntensive Care Unit, Shaare Zedek Medical Center, Jerusalem 91120, Israel.
Leonid SternikDepartment of Cardiac Surgery, The Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Tel Aviv 6423906, Israel.
Gil BolotinDepartment of Cardiac Surgery, Rambam Medical Center, Haifa 3525408, Israel.
Roberto LorussoCardiovascular Research Institute, Maastricht (CARIM), 6200 Maastricht, The Netherlands.
Yigal KassifDepartment of Cardiac Surgery, The Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Tel Aviv 6423906, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn March 2020, COVID-19 was announced as a global pandemic. The first COVID-19 patient was connected to an ECMO device in Israel during that time. Since then, over 200 patients have required ECMO support due to COVID-19 infection. The present study is a multi-institutional analysis of all COVID-19 patients requiring veno-venous (VV) ECMO in Israel. The aim was to characterize and compare the survivors and deceased patients as well as establish risk factors for mortality.

methodsThis retrospective multi-institutional study was conducted from March 2020 to March 2021 in eleven of twelve ECMO centers operating in Israel. All COVID-19 patients on VV ECMO support were included in the cohort. The patients were analyzed based on their comorbidities, procedural data, adverse event on ECMO, and outcomes. Univariate and multivariate analyses were used to compare the deceased and the surviving patients.

resultsThe study included 197 patients, of which 150 (76%) were males, and the mean age was 50.7 ± 12 years. Overall mortality was 106 (54%). Compared with the deceased subjects, survivors were significantly younger (48 ± 11 vs. 53 ± 12 years), suffered less from ischemic heart disease (IHD) (3% vs. 12%), and were ventilated for a significantly shorter period (≤4 days) prior to cannulation (77% vs. 63%). Patients in the deceased group experienced more kidney failure and sepsis. Rates of other complications were comparable between groups.

conclusionsBased on this study, we conclude that early cannulation (≤4 days) of younger patients (≤55 years) may improve overall survival and that a history of IHD might indicate a reduced prognosis.

Indexed as

COVID-19ECMOmechanical ventilation

Identifiers

PMID36679953
PMCPMC9865577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.