Evidence map›Paper›PMID 36679351›Full record

ArticlePolymers2023

Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability.

Md Sohanur Rahman Sohan, Samar Elshamy, Grace Lara-Valderrama, Teetach Changwatchai, Kubra Khadizatul, Isao Kobayashi, Mitsutoshi Nakajima, Marcos A Neves

Abstract read
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Antifungal Effects ofPathogens (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Encapsulation of D-limonene inCurrent research in food science · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Sohanur Rahman SohanGraduate School of Science and Technology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.ORCID 0000-0002-3064-5657
Samar ElshamySchool of Integrative and Global Majors, Tsukuba Life Science Innovation Program, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.ORCID 0000-0001-7497-3663
Grace Lara-ValderramaFood Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
Teetach ChangwatchaiSchool of Integrative and Global Majors, Tsukuba Life Science Innovation Program, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.ORCID 0000-0001-9241-9885
Kubra KhadizatulGraduate School of Life and Environmental Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Isao KobayashiFood Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
Mitsutoshi NakajimaAlliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Marcos A NevesFaculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.ORCID 0000-0002-7159-549X

Funding

University of Tsukuba This research was partially funded by the program for promoting Grant-in-Aid for Scientific Research Applications FY 2021 from the Faculty of Life and Environmental Sciences, University of Tsukuba (Recipient: M.A.N).
6 · The paper itself

Abstract

The present study aimed to investigate the physical stability in terms of (droplet size, pH, and ionic strength) and chemical stability in terms of (retention) of D-limonene (LM) in the nanoemulsions after emulsification as well as after storing them for 30 days under different temperatures (5 °C, 25 °C, and 50 °C). LM is a cyclic monoterpene and a major component extracted from citrus fruits. The modification of disperse phase with soybean oil (SB) and a nonionic emulsifier (Tween 80) was adequate to prepare stable LM-loaded nanoemulsions. LM blended with SB-loaded nanoemulsions were stable against droplet growth over pH (3-9) and ionic strength (0-500 mM NaCl). Regarding long-term storage, the prepared nanoemulsions demonstrated excellent physical stability with droplet size ranging from 120-130 nm during 30 days of storage at both 5 °C and 25 °C; however, oiling off started in the emulsions, which were stored at 50 °C from day 10. On the other hand, the retention of LM in the emulsions was significantly impacted by storage temperature. Nanoemulsions stored at 5 °C had the highest retention of 91%, while nanoemulsions stored at 25 °C had the lowest retention of 82%.

Indexed as

D-limoneneenvironmental stressO/W emulsionretentionstorage stabilitytriglycerides

Identifiers

PMID36679351
PMCPMC9864102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.