ArticlePolymers2023
Synthesis of Cellulose Nanoparticles from Ionic Liquid Solutions for Biomedical Applications.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Stabilization of Nanodispersed Cerium Phosphate in Matrices Containing Cellulose Derivatives, Citric Acid and Metronidazole.Polymers · 2026Article
- The journey of bioactive peptides in vivo: cutting-edge advances in absorption, transport, and bioavailability.Bioprocess and biosystems engineering · 2026Review
- Design and characterization of Zn-integrated cellulose nanoparticle derived from sugarcane bagasse for biomedical applications.Discover nano · 2026Article
- Domain Segregation in Ionic Liquids Induces Long-Range Oscillatory Forces between Nanoparticles and Surfaces.ACS nanoscience Au · 2025Article
- A Review of Patents and Innovative Biopolymer-Based Hydrogels.Gels (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A method for the synthesis of cellulose nanoparticles using the ionic liquid 1-ethyl-3-methylimidazolium acetate has been optimised. The use of a highly biocompatible biopolymer such as cellulose, together with the use of an ionic liquid, makes this method a promising way to obtain nanoparticles with good capability for drug carrying. The operating conditions of the synthesis have been optimised based on the average hydrodynamic diameter, the polydispersity index, determined by Dynamic Light Scattering (DLS) and the Z-potential, obtained by phase analysis light scattering (PALS), to obtain cellulose nanoparticles suitable for use in biomedicine. The obtained cellulose nanoparticles have been characterised by Fourier transform infrared spectroscopy (FTIR) with attenuated total reflectance (ATR), field emission scanning electron microscopy (FESEM) and thermogravimetric analysis (TGA/DTA). Finally, cell viability studies have been performed with a cancer cell line (HeLa) and with a healthy cell line (EA.hy926). These have shown that the cellulose nanoparticles obtained are not cytotoxic in the concentration range of the studied nanoparticles. The results obtained in this work constitute a starting point for future studies on the use of cellulose nanoparticles, synthesised from ionic liquids, for biomedical applications such as targeted drug release or controlled drug release.
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Registered trials
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