Evidence map›Paper›PMID 36678925›Full record

ArticlePharmaceutics2023

The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants.

Philipp F Popp, Tania Lozano-Cruz, Franziska Dürr, Addis Londaitsbehere, Johanna Hartig, Francisco Javier de la Mata, Rafael Gómez, Thorsten Mascher, Ainhoa Revilla-Guarinos

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Philipp F PoppDepartment of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, 01217 Dresden, Germany.ORCID 0000-0002-7825-1550
Tania Lozano-CruzDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. Del Río" (IQAR), University de Alcalá, 28805 Madrid, Spain.
Franziska DürrDepartment of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, 01217 Dresden, Germany.
Addis LondaitsbehereDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. Del Río" (IQAR), University de Alcalá, 28805 Madrid, Spain.
Johanna HartigDepartment of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, 01217 Dresden, Germany.
Francisco Javier de la MataDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. Del Río" (IQAR), University de Alcalá, 28805 Madrid, Spain.ORCID 0000-0003-0418-3935
Rafael GómezDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. Del Río" (IQAR), University de Alcalá, 28805 Madrid, Spain.ORCID 0000-0001-6448-2414
Thorsten MascherDepartment of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, 01217 Dresden, Germany.ORCID 0000-0002-6300-5541
Ainhoa Revilla-GuarinosDepartment of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, 01217 Dresden, Germany.ORCID 0000-0002-9894-3538
Technische Universität Dresden · DEUniversidad de Alcalá · ES

Funding

NIMHD NIH HHS L60 MD003733
6 · The paper itself

Abstract

The threat of antimicrobial-resistant bacteria is ever increasing and over the past-decades development of novel therapeutic counter measurements have virtually come to a halt. This circumstance calls for interdisciplinary approaches to design, evaluate and validate the mode of action of novel antibacterial compounds. Hereby, carbosilane dendritic systems that exhibit antimicrobial properties have the potential to serve as synthetic and rationally designed molecules for therapeutic use. The bow-tie type topology of BDTL049 was recently investigated against the Gram-positive model organism

Indexed as

antimicrobial resistanceBacillus subtiliscarbosilane dendritic systemcell envelope stress responseclick chemistrydrug designfluorescent microscopymembrane labelingmode of actionnovel synthetic antibiotic

Identifiers

PMID36678925
PMCPMC9866484
OpenAlexW4316464122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.