Evidence map›Paper›PMID 36678914›Full record

ArticlePharmaceutics2023

The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation.

Johanes K Kasim, Jiwon Hong, Anthony J R Hickey, Anthony R J Phillips, John A Windsor, Paul W R Harris, Margaret A Brimble, Iman Kavianinia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Johanes K KasimSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
Jiwon HongSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.ORCID 0000-0003-0936-3281
Anthony J R HickeySchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
Anthony R J PhillipsSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.ORCID 0000-0001-6143-5866
John A WindsorMaurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
Paul W R HarrisSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
Margaret A BrimbleSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.ORCID 0000-0002-7086-4096
Iman KavianiniaSchool of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.ORCID 0000-0002-2446-1376
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma remains a highly debilitating condition with no effective disease-modifying interventions. In our search for natural products with promising anticancer activity, we identified the aminolipopeptide trichoderin A as a potential candidate. While it was initially isolated as an antitubercular peptide, we provide evidence that it is also selectively toxic against BxPC-3 and PANC-1 human pancreatic ductal adenocarcinoma cells cultured under glucose deprivation. This has critical implications for the pancreatic ductal adenocarcinoma, which is characterized by nutrient deprivation due to its hypovascularized network. We have also successfully simplified the trichoderin A peptide backbone, allowing greater accessibility to the peptide for further biological testing. In addition, we also conducted a preliminary investigation into the role of peptide lipidation at the

Indexed as

aminolipopeptideanticancer peptidecancer metabolismglucose dependencypancreatic ductal adenocarcinomatrichoderin A

Identifiers

PMID36678914
PMCPMC9866366
OpenAlexW4316464358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.