Evidence map›Paper›PMID 36678904›Full record

ArticlePharmaceutics2023

Synergistic Pro-Apoptotic Effect of a Cyclic RGD Peptide-Conjugated Magnetic Mesoporous Therapeutic Nanosystem on Hepatocellular Carcinoma HepG2 Cells.

Xuanping Zhao, Chuan Liu, Zichao Wang, Yingyuan Zhao, Xuyang Chen, Haizhen Tao, Hong Chen, Xueqin Wang, Shaofeng Duan

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xuanping ZhaoCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Chuan LiuCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Zichao WangCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.ORCID 0000-0001-5375-2669
Yingyuan ZhaoCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Xuyang ChenCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Haizhen TaoCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Hong ChenCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Xueqin WangCollege of Bioengineering, Henan University of Technology, Zhengzhou 450001, China.
Shaofeng DuanInstitute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, Kaifeng 475004, China.ORCID 0000-0003-2151-082X
Henan University of Technology · CNHenan University · CN

Funding

Innovative Funds Plan of Henan University of Technology 2020ZKCJ23Young Core Instructor Program from Henan University of Technology No.21420055Young Core Instructor Program in Higher Education Institution of Henan province No.2018GGJS067
6 · The paper itself

Abstract

Numerous nanocarriers have been developed to deliver drugs for the treatment of hepatocellular carcinoma. However, the lack of specific targeting ability, the low administration efficiency, and insufficient absorption by hepatocellular carcinoma cells, severely limits the therapeutic effect of the current drugs. Therefore, it is still of great clinical significance to develop highly efficient therapies with few side effects for the treatment of hepatocellular carcinoma. Herein, we developed a highly effective nanocarrier, cyclic RGD peptide-conjugated magnetic mesoporous nanoparticles (

Indexed as

anticancer drug deliveryapoptosiscyclic RGD peptidehepatocellular carcinomatargeted nanoparticles

Identifiers

PMID36678904
PMCPMC9866545
OpenAlexW4315797805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.