Evidence map›Paper›PMID 36678854›Full record

ArticlePharmaceutics2023

Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers.

Maokai Xu, Maria Antonova, Pavel Salavei, Katharina Illek, Ana Valeria Meléndez, Ramin Omidvar, Roland Thuenauer, Olga Makshakova, Winfried Römer

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Maokai XuFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-6267-3070
Maria AntonovaKazan Institute for Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 420111 Kazan, Russia.
Pavel SalaveiFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Katharina IllekFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Ana Valeria MeléndezFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Ramin OmidvarFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0003-1170-1382
Roland ThuenauerFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Olga MakshakovaFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-0615-3513
Winfried RömerFaculty of Biology, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-2847-246X
University of Freiburg · DEKazan Institute of Biochemistry and Biophysics · RUUniversität Hamburg · DE

Funding

RTG 2202 ('Transport across and into membranes'), by the Ministry for Science, Research and Arts of the State of Baden-Württemberg, and by the Freiburg Institute for Advanced Studies (FRIAS) Az: 33-7532.20the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy EXC-294 and EXC-2189
6 · The paper itself

Abstract

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand-receptor pair based on a dimeric, engineered derivative of the

Indexed as

accelerated molecular dynamicsdrug carrierGb3-binding lectinglycosphingolipidprotein engineeringprotein structuretranscytosisvalency

Identifiers

PMID36678854
PMCPMC9864468
OpenAlexW4315486595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.