Evidence map›Paper›PMID 36678755›Full record

ArticlePharmaceutics2022

Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines.

Timur R Nizamov, Artem R Iliasov, Stepan S Vodopyanov, Irina V Kozhina, Igor G Bordyuzhin, Dmitry G Zhukov, Anna V Ivanova, Elizaveta S Permyakova, Pavel S Mogilnikov, Daniil A Vishnevskiy and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Hybrid FeInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Timur R NizamovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.ORCID 0000-0002-2344-0274
Artem R IliasovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.ORCID 0000-0002-2444-4306
Stepan S VodopyanovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.ORCID 0000-0003-1429-9835
Irina V KozhinaDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Igor G BordyuzhinDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Dmitry G ZhukovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Anna V IvanovaDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Elizaveta S PermyakovaDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.ORCID 0000-0003-2581-0803
Pavel S MogilnikovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Daniil A VishnevskiyDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Igor V ShchetininDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
Maxim A AbakumovDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.ORCID 0000-0003-2622-9201
Alexander G SavchenkoDepartment of Physical Materials Science, National University of Science and Technology (MISIS), Moscow 119049, Russia.
National University of Science and Technology · RUPirogov Russian National Research Medical University · RU

Funding

Russian Foundation for Basic Research 20-03-00967This work was funded by the Ministry of Science and Higher Education of the Russian Federation under the strategic academic leadership program "Priority 2030". P2030
6 · The paper itself

Abstract

Redox-responsive and magnetic nanomaterials are widely used in tumor treatment separately, and while the application of their combined functionalities is perspective, exactly how such synergistic effects can be implemented is still unclear. This report investigates the internalization dynamics of magnetic redox-responsive nanoparticles (MNP-SS) and their cytotoxicity toward PC-3 and 4T1 cell lines. It is shown that MNP-SS synthesized by covalent grafting of polyethylene glycol (PEG) on the magnetic nanoparticle (MNP) surface via SS-bonds lose their colloidal stability and aggregate fully in a solution containing DTT, and partially in conditioned media, whereas the PEGylated MNP (MNP-PEG) without S-S linker control remains stable under the same conditions. Internalized MNP-SS lose the PEG shell more quickly, causing enhanced magnetic core dissolution and thus increased toxicity. This was confirmed by fluorescence microscopy using MNP-SS dual-labeled by Cy3 via labile disulfide, and Cy5 via a rigid linker. The dyes demonstrated a significant difference in fluorescence dynamics and intensity. Additionally, MNP-SS demonstrate quicker cellular uptake compared to MNP-PEG, as confirmed by TEM analysis. The combination of disulfide bonds, leading to faster dissolution of the iron oxide core, and the high-oxidative potential Fe

Indexed as

cytotoxicitydisulfidesmagnetic nanoparticlesredox-responsive materialstumor cells

Identifiers

PMID36678755
PMCPMC9864410
OpenAlexW4313319304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.