In one paragraphArticle in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors at 3 institutions in 1 country.
Joaquín BonelliDepartament de Química Inorgànica i Orgànica, Secció de Química Orgànica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona (UB), Martí i Franquès 1-11, E-08028 Barcelona, Spain.ORCID 0000-0003-4958-373X María Velasco-de AndrésImmunoreceptors del Sistema Innat i Adaptatiu, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-151, E-08036 Barcelona, Spain.
Neus IsidroNanobiotechnological Polymers Division Ecopol Tech, S.L., El Foix Business Park, Indústria 7, L'Arboç del Penedès, E-43720 Tarragona, Spain.ORCID 0000-0003-4459-6881 Cristina BayóServei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Villarroel 170, E-08036 Barcelona, Spain.ORCID 0000-0002-7077-6213 Sergi ChumillasDepartament de Química Inorgànica i Orgànica, Secció de Química Orgànica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona (UB), Martí i Franquès 1-11, E-08028 Barcelona, Spain.ORCID 0000-0002-0173-6031 Laura Carrillo-SerradellImmunoreceptors del Sistema Innat i Adaptatiu, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-151, E-08036 Barcelona, Spain.
Sergi Casadó-LlombartImmunoreceptors del Sistema Innat i Adaptatiu, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-151, E-08036 Barcelona, Spain.
Cheryl MokServei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Villarroel 170, E-08036 Barcelona, Spain.
Daniel Benítez-RibasServei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Villarroel 170, E-08036 Barcelona, Spain.ORCID 0000-0002-2346-5324 Francisco LozanoImmunoreceptors del Sistema Innat i Adaptatiu, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-151, E-08036 Barcelona, Spain.ORCID 0000-0003-1119-4368 Josep RocasNanobiotechnological Polymers Division Ecopol Tech, S.L., El Foix Business Park, Indústria 7, L'Arboç del Penedès, E-43720 Tarragona, Spain.ORCID 0000-0001-7450-0225 Vicente MarchánDepartament de Química Inorgànica i Orgànica, Secció de Química Orgànica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona (UB), Martí i Franquès 1-11, E-08028 Barcelona, Spain.ORCID 0000-0002-1905-2156 Hospital Clínic de Barcelona · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESInstitut de Biomedicina de la Universitat de Barcelona
Funding
Agencia Estatal de Investigación CTQ2017-84779-RAgencia Estatal de Investigación PID2020-117508RB-I00Generalitat de Catalunya-AGAUR 2017 DI 072Generalitat de Catalunya-AGAUR RD17-1-0079Ministerio de Ciencia e Innovación CTQ2017-84779-RMinisterio de Ciencia e Innovación PID2020-117508RB-I00
6 · The paper itselfAbstract
Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs' surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer.
Indexed as
bioimagingdrug deliverynanoencapsulationpolyurethane-polyurea nanoparticlestumor-targeting
Identifiers
PMID36678687
PMCPMC9862617
OpenAlexW4313245443
What OpenQuestion holds
Textmetadata
LicenceCC BY
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