Evidence map›Paper›PMID 36678677›Full record

ArticlePharmaceutics2022

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol's Anti-Tumor Angiogenesis Effect.

Gaofu Li, Lei Zhou, Huifang Deng, Congshu Huang, Ningning Wang, Lanxin Yue, Pengfei Zhang, Yongqiang Zhou, Wei Zhou, Yue Gao

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  2. Article
  3. The Multifaceted Role of Mitochondria in Angiogenesis.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gaofu LiDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Lei ZhouSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Huifang DengDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Congshu HuangSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Ningning WangDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Lanxin YueDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Pengfei ZhangDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yongqiang ZhouDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Wei ZhouDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0003-0435-7261
Yue GaoDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Tianjin University of Traditional Chinese Medicine · CNGuangdong Pharmaceutical University · CN

Funding

National Nature Science Foundation of China 82274198
6 · The paper itself

Abstract

Celastrol, an active triterpenoid extracted from one of the most famous traditional Chinese medicines (TCMs),

Indexed as

celastrolmitochondrion-targeted medicineOPA1tumor angiogenesis

Identifiers

PMID36678677
PMCPMC9866574
OpenAlexW4313202801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.