Evidence map›Paper›PMID 36678657›Full record

ArticlePharmaceutics2022

The Quest for Child-Friendly Carrier Materials Used in the 3D Semi-Solid Extrusion Printing of Medicines.

Eveline E M van Kampen, Sejad Ayyoubi, Luc Willemsteijn, Kjeld J C van Bommel, Elisabeth J Ruijgrok

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eveline E M van KampenErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-8576-9940
Sejad AyyoubiErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-6251-2517
Luc WillemsteijnErasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Department of Hospital Pharmacy, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-8855-8548
Kjeld J C van BommelThe Netherlands Organization for Applied Scientific Research (TNO), 5656 NL Eindhoven, The Netherlands.
Elisabeth J RuijgrokErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, 3015 GD Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work gives a brief overview of carrier materials currently used in pharmaceutical studies on the three-dimensional (3D) semi-solid extrusion (SSE) printing of medicines for pediatrics. The suitability of using these carrier materials in pediatric formulations, concerning safety and toxicity, was reviewed by consulting the 'Safety & Toxicity of Excipients for Pediatrics' (STEP) database and the Food and Drug Administration (FDA) regulations. In the second part of this work, carrier materials were tested on their ability to form a semi-solid mixture with lactose by dual asymmetric centrifugation (DAC) and printing by SSE. With the combination of theoretical and experimental studies, this work will guide research toward grounded decision-making when it comes to carrier material selection for pharmaceutical pediatric 3D SSE printing formulations.

Indexed as

childrendual asymmetric centrifugationpharmaceutical preparationspharmaceutical technologysemi-solid extrusionthree-dimensional printing

Identifiers

PMID36678657
PMCPMC9865971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.