Evidence map›Paper›PMID 36678650›Full record

ReviewPharmaceutics2022

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System.

Tianwei Li, Xiaoqing Li, Guiping Han, Ming Liang, Zongrui Yang, Congyi Zhang, Shizhuan Huang, Sheng Tai, Shan Yu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
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  17. RSC advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tianwei LiDepartment of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Xiaoqing LiDepartment of Pathology, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Guiping HanDepartment of Pathology, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Ming LiangDepartment of Infectious Diseases, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Zongrui YangDepartment of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Congyi ZhangDepartment of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Shizhuan HuangDepartment of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Sheng TaiDepartment of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Shan YuDepartment of Pathology, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CN

Funding

National Natural Science Foundation of China 81972724
6 · The paper itself

Abstract

Drug delivery system (DDS) realizes the drug delivery process through the drug carrier. As an important part of DDS, the selection of the drug carrier material is extremely critical, which requires the carrier material to possess excellent biocompatibility and targeting and not affect the pharmacological action of the drug. As one of the endogenous extracellular vesicles, exosomes are 30-100 nm in diameter, which are considered a new generation of a natural nanoscale delivery system. Exosomes secreted by different types of cells carry signaling molecules (such as proteins and nucleic acid) playing an important role in cell behaviors. Owing to their ability to specialize in intercellular communication, exosomes provide a distinctive method to deliver therapeutic drugs to target cells. In this concept, exosomes as the natural liposomes carry endogenous biomolecules, have excellent biocompatibility, and could be loaded with cargo both in vivo and in vitro. In addition, modifications by genetic and/or chemical engineering to part of the exosome surface or complement the desired natural effect may enhance the targeting with drug loading capability. Notably, exosomes weakly react with serum proteins prolonging cargo half-life. Overall, exosomes as natural carriers integrate the superiority of synthetic nanocarriers and cellular communication while precluding their limitations, which provides novel and reliable methods for drug delivery and treatment. Our review focuses on the therapeutic potentials and clinical values of exosomes as a carrier of drug delivery system in multiple diseases, including cancer, nervous, immune, and skeletal system diseases.

Indexed as

CNS diseasedrug delivery systemexosomeexosome carrierstumor

Identifiers

PMID36678650
PMCPMC9865231
OpenAlexW4313469795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.