Evidence map›Paper›PMID 36678600›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway.

Luana Pereira Cardoso, Stefanie Oliveira de Sousa, Juliana Prado Gusson-Zanetoni, Laura Luciana de Melo Moreira Silva, Barbara Maria Frigieri, Tiago Henrique, Eloiza Helena Tajara, Sonia Maria Oliani, Flávia Cristina Rodrigues-Lisoni

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  6. The Hidden Power of Black Pepper: Exploring Piperine's Role in Cancer.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luana Pereira CardosoSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.
Stefanie Oliveira de SousaSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.ORCID 0000-0001-8049-8643
Juliana Prado Gusson-ZanetoniSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.
Laura Luciana de Melo Moreira SilvaSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.
Barbara Maria FrigieriSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.
Tiago HenriqueDepartment of Molecular Biology, School of Medicine of Sao José do Rio Preto (FAMERP), Sao José do Rio Preto 15090-000, Brazil.
Eloiza Helena TajaraDepartment of Molecular Biology, School of Medicine of Sao José do Rio Preto (FAMERP), Sao José do Rio Preto 15090-000, Brazil.
Sonia Maria OlianiSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.ORCID 0000-0003-0918-2130
Flávia Cristina Rodrigues-LisoniSão Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.ORCID 0000-0002-8855-9049
Universidade Estadual Paulista (Unesp) · BRFaculdade de Medicina de São José do Rio Preto · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). 0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 88887.482914/2020-00São Paulo Research Foundation 2017 / 02100-3
6 · The paper itself

Abstract

Cervical cancer is the fourth-most common type of cancer in the world that causes death in women. It is mainly caused by persistent infection by human papillomavirus (HPV) that triggers a chronic inflammatory process. Therefore, the use of anti-inflammatory drugs is a potential treatment option. The effects of piperine, an amino alkaloid derived from

Indexed as

alkaloidgynecological cancerherbal medicinespiperine

Identifiers

PMID36678600
PMCPMC9866887
OpenAlexW4315628477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.