Evidence map›Paper›PMID 36678522›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Glucose Uptake Is Increased by Estradiol Dipropionate in L6 Skeletal Muscle Cells.

Yanhong Yao, Xinzhou Yang, Jinhua Shen, Ping Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yanhong YaoHubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area, Institute for Medical Biology, College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.ORCID 0000-0003-1389-2063
Xinzhou YangSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.ORCID 0000-0003-1697-2923
Jinhua ShenHubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area, Institute for Medical Biology, College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.
Ping ZhaoHubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area, Institute for Medical Biology, College of Life Sciences, South-Central Minzu University, Wuhan 430074, China.ORCID 0000-0002-5348-6126
China International Science and Technology Cooperation · CNMinzu University of China · CN

Funding

Key Laboratory Construction of Hubei Province 2018BFC360
6 · The paper itself

Abstract

GLUT4 is an important glucose transporter, which is closely related to insulin resistance and type 2 diabetes. In this study, we investigated the mechanism of Estradiol Dipropionate (EDP) on uptake of glucose in L6 skeletal muscle cells. In our study, we confirmed that EDP promoted uptake of glucose in L6 skeletal muscle cells in both normal and insulin resistant models. Western blot indicated that EDP accelerated GLUT4 expression and significantly activated AMPK and PKC phosphorylation; the expression of GLUT4 was significantly inhibited by AMPK inhibitor compound C and PKC inhibitor Gö6983, but not by Wortmannin (Akt inhibitor). Meanwhile, EDP boosted GLUT4 expression, and also increased intracellular Ca

Indexed as

Ca2+Estradiol Dipropionateglucose transporter 4L6 skeletal muscle cellstype 2 diabetes

Identifiers

PMID36678522
PMCPMC9866800
OpenAlexW4313244931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.