Evidence map›Paper›PMID 36678504›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Biological Screening of

Rizwan Ahmad, Aljawharah Alqathama, Mohammed Aldholmi, Muhammad Riaz, Mohammed H Mukhtar, Fatema Aljishi, Ebtihal Althomali, Muntathir Ali Alamer, Mohammed Alsulaiman, Abdulmalik Ayashy and 1 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Plants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Antidiabetic and Anticancer Potentials ofPharmaceuticals (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rizwan AhmadDepartment of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.ORCID 0000-0001-6490-8219
Aljawharah AlqathamaDepartment of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-0855-2013
Mohammed AldholmiDepartment of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.ORCID 0000-0003-3270-0338
Muhammad RiazDepartment of Pharmacy, Shaheed Benazir Bhutto University, Sheringal 18050, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-9327-1368
Mohammed H MukhtarFaculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Fatema AljishiDepartment of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ebtihal AlthomaliDepartment of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Muntathir Ali AlamerPrince Sultan Cardiac Center, Al Sulimaniyah 4th, Al Hofuf 36441, Saudi Arabia.
Mohammed AlsulaimanCollege of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.ORCID 0000-0001-8597-4119
Abdulmalik AyashyCollege of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.
Mohsen AlshowaikiCollege of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGeographical variation may affect the phytochemistry as well as the biological activities of Glycyrrhiza glabra (licorice) root. Herein, a series of biological activities were performed to evaluate the impact of geographical origin on the biological potential of eight different licorice samples. METHODOLOGY: Cell culture studies were performed for cytotoxicity (MCF7, HCT116, HepG2, and MRC5), glucose uptake assay (HepG2), and glutathione peroxidase activity (HepG2), whereas α-amylase inhibition activity was tested for antidiabetic potential.

resultsThe Indian sample was observed to be more cytotoxic against MCF7 (22%) and HCT116 (43%) with an IC

conclusionThe licorice samples exhibited significant cytotoxic, GPx, and α-amylase inhibitory activity. The samples with higher extract yield showed more potential in these biological activities.

Indexed as

antidiabeticglucose uptakeglutathione peroxidaselicoricePCA

Identifiers

PMID36678504
PMCPMC9860537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.