Evidence map›Paper›PMID 36678443›Full record

ArticlePathogens (Basel, Switzerland)2023

Excretory/Secretory Proteome of Females and Males of the Hookworm

Samuel C Uzoechi, Bruce A Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K Bracken, Paul J Brindley, R Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi and 5 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Samuel C UzoechiDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bruce A RosaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6820-446X
Kumar Sachin SinghDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Young-Jun ChoiDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bethany K BrackenCharles River Analytics, Inc., Cambridge, MA 02138, USA.
Paul J BrindleyDepartment of Microbiology, Immunology & Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, USA.ORCID 0000-0003-1765-0002
R Reid TownsendDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert SprungDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2368-8859
Bin ZhanDepartment of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6884-9452
Maria-Elena BottazziDepartment of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8429-0476
John M HawdonDepartment of Microbiology, Immunology & Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, USA.ORCID 0000-0002-6164-1413
Yide WongCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns 4878, Australia.ORCID 0000-0001-6049-0177
Alex LoukasCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns 4878, Australia.ORCID 0000-0002-0896-8441
Sergej DjuranovicDepartment of Cell Biology and Physiology, Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9417-0822
Makedonka MitrevaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9572-3436

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
MECHANISMS FOR MODULATION OF MIRNA-MEDIATED GENE SILENCINGR01GM112824 · NIGMS · WASHINGTON UNIVERSITY · PI DJURANOVIC, SERGEJ · 2015 to 2023
$3.1M
Dissecting mRNA-ribosome interaction in AU-rich transcriptome of Plasmodium falciparumR01GM136823 · NIGMS · WASHINGTON UNIVERSITY · PI DJURANOVIC, SERGEJ · 2021 to 2024
$1.4M
Defense Advanced Research Projects Agency Contract No. N66001-21-C-4013Naval Information Warfare Center Pacific Contract No. N66001-21-C-4013NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R01 GM112824NIGMS NIH HHS R01 GM136823Siteman Comprehensive Cancer Center Support Grant NCI P30 CA091842Washington University in St. Louis Institute of Clinical and Translational Sciences NCATS UL1 TR000448Washington University in St. Louis Mass Spectrometry Research Resource NIGMS P41 GM103422
6 · The paper itself

Abstract

The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm's excretory/secretory products (ESPs), which have a wide spectrum of biological functions. We used ultra-high performance mass spectrometry to comprehensively profile and compare female and male ESPs from the zoonotic human hookworm

Indexed as

Ancylostoma ceylanicumESPexcretory/secretoryhookwormproteomics

Identifiers

PMID36678443
PMCPMC9865600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.