Evidence map›Paper›PMID 36678401›Full record

ArticlePathogens (Basel, Switzerland)2022

Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B.

Janett Fischer, Shuang Long, Eleni Koukoulioti, Tobias Müller, Balazs Fueloep, Renate Heyne, Mohammed Eslam, Jacob George, Fabian Finkelmeier, Oliver Waidmann and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Gene variants, oxidative stress and inflammation in Colombian populationsBiomedica : revista del Instituto Nacional de Salud · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Janett FischerDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.ORCID 0000-0002-8710-101X
Shuang LongDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.
Eleni KoukouliotiDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.ORCID 0000-0002-8791-9954
Tobias MüllerDepartment of Medicine-Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, 14197 Berlin, Germany.ORCID 0000-0003-3426-5421
Balazs FueloepDepartment of Gastroenterology, Kantonsspital Baselland, 4410 Liestal, Switzerland.
Renate HeyneLiver and Study Center Checkpoint, 10969 Berlin, Germany.
Mohammed EslamStorr Liver Centre, Westmead Hospital and Westmead Millennium Institute for Medical Research, University Sydney, Sydney 2006, Australia.
Jacob GeorgeStorr Liver Centre, Westmead Hospital and Westmead Millennium Institute for Medical Research, University Sydney, Sydney 2006, Australia.
Fabian FinkelmeierDepartment of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, 60528 Frankfurt, Germany.ORCID 0000-0001-8559-9910
Oliver WaidmannCenter for Hematology and Oncology Bethanien, 60389 Frankfurt, Germany.
Thomas BergDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.ORCID 0000-0003-0003-6241
Florian van BömmelDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.ORCID 0000-0003-2679-0672
Leipzig University · DEWestmead Hospital · AUCardiovascular Center Bethanien · DECharité - Universitätsmedizin Berlin · DEGoethe University Frankfurt · DEKantonsspital Baselland · CHNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-1 beta (IL-1β) promotes liver disease progression and hepatocarcinogenesis in chronic hepatitis B (CHB). Single nucleotide polymorphisms (SNPs) within the promotor region of the

Indexed as

liver cancerproinflammatory cytokinerisk variant

Identifiers

PMID36678401
PMCPMC9861021
OpenAlexW4313327623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.