Evidence map›Paper›PMID 36678330›Full record

ArticleNutrients2023

Natural Activators of Autophagy Reduce Oxidative Stress and Muscle Injury Biomarkers in Endurance Athletes: A Pilot Study.

Alessandra D'Amico, Chiara Fossati, Fabio Pigozzi, Paolo Borrione, Mariangela Peruzzi, Simona Bartimoccia, Filippo Saba, Annachiara Pingitore, Giuseppe Biondi-Zoccai, Luigi Petramala and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Alessandra D'AmicoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.ORCID 0000-0002-5571-4583
Chiara FossatiDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.ORCID 0000-0002-2870-7185
Fabio PigozziDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.ORCID 0000-0001-5808-9405
Paolo BorrioneDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Mariangela PeruzziDepartment of Clinical Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Simona BartimocciaDepartment of Clinical Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Filippo SabaFondazione Santa Lucia IRCCS, 00179 Roma, Italy.
Annachiara PingitoreDepartment of General and Specialistic Surgery "Paride Stefanini", Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9419-0858
Giuseppe Biondi-ZoccaiMediterranea Cardiocentro, 80122 Naples, Italy.ORCID 0000-0001-6103-8510
Luigi PetramalaDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4463-4956
Fabrizio De GrandisVilla Stuart Sport Clinic, FIFA Medical Centre of Excellence, 00135 Rome, Italy.
Daniele VecchioDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
Luca D'AmbrosioDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-8196-8069
Sonia SchiavonDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
Luigi SciarraDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences, University of L'Aquila, 67100 Coppito, Italy.ORCID 0000-0002-9669-1330
Cristina NocellaDepartment of Clinical Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Elena CavarrettaMediterranea Cardiocentro, 80122 Naples, Italy.ORCID 0000-0003-0221-6000
Sapienza University of Rome · ITForo Italico University of Rome · ITClinica Mediterranea · ITFondazione Santa Lucia · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress and impaired autophagy are directly and indirectly implicated in exercise-mediated muscle injury. Trehalose, spermidine, nicotinamide, and polyphenols possess pro-autophagic and antioxidant properties, and could therefore reduce exercise-induced damage to skeletal muscle. The aim of this study was to investigate whether a mixture of these compounds was able to improve muscle injury biomarkers in endurance athletes through the modulation of oxidative stress and autophagic machinery. METHODS AND

resultssNOX2-dp; H

conclusionSupplementation with this mixture positively affected redox state and autophagy and improved muscle injury biomarkers in athletes, allowing for better muscle recovery. Moreover, it is speculated that this mixture could also benefit patients suffering from muscle injuries, such as cancer or cardiovascular patients, or elderly subjects.

Indexed as

Hydrogen PeroxideOxidative StressAgedAntioxidantsAthletesAutophagyBiomarkersHumansMuscle, SkeletalPilot ProjectsAntioxidantsBiomarkersHydrogen Peroxideathletesautophagymuscle injuryoxidative stresspolyphenolstrehalose

Identifiers

PMID36678330
PMCPMC9862446
OpenAlexW4316465938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.