ReviewNutrients2023
Sodium Homeostasis, a Balance Necessary for Life.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 79 citations in OpenAlex.
- Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity.Nutrients · 2024Trial
- Multiple electrolyte imbalances in hospitalized patients: a multimorbidity perspective from a large, retrospective cohort study.Annals of medicine · 2026Article
- Table salt as a salivary stimulant and buffer substitute in calf diets: Effects on growth performance, rumen fermentation, and economics.Veterinary and animal science · 2026Article
- Investigation of a surface decorated Ag-MnORSC advances · 2026Article
- Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues.The Journal of endocrinology · 2026Review
- The 'Chloride Theory' for Heart Failure Pathophysiology: An Updated Narrative Review 2025.Cardiology and therapy · 2026Review
- A Comparison of Mere-Exposure, Flavor-Flavor and Flavor-Nutrient Learning Strategies in Enhancing Legume Preferences in an Adult Sample.Foods (Basel, Switzerland) · 2026Article
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Differences in α-synuclein conformational states in physiologically relevant pH/NaThe Analyst · 2026Article
- The Potential Impact of Serum Sodium and Potassium Levels on Sensorineural Hearing Loss and Tinnitus.Journal of clinical medicine · 2026Article
- Abnormal circadian pattern of urinary sodium excretion and chronic kidney disease progression.BMC nephrology · 2026Article
- Trafficking of the human NaProtein science : a publication of the Protein Society · 2026Article
- Review
- Sodium and Water Homeostasis in Children: Pathogenesis, Diagnosis, and Treatment.Journal of clinical medicine · 2026Review
- The Changing Landscape of Sodium Needs in the Preterm Neonate for Optimizing Growth and Development.Nutrients · 2026Review
- Applying the extended health belief model to understand salt-reduction behaviors among Saudi adults: a cross-sectional study.Frontiers in public health · 2026Article
- Chicken Liver from Broilers Fed Wheat Germ Expeller: A Source of Minerals and Energy in the Human Diet.Foods (Basel, Switzerland) · 2025Article
- Neurogenic organ dysfunction syndrome after acute brain injury.Military Medical Research · 2025Review
- Comparison of the Effects of Carbetocin and Oxytocin Injections in the Prevention of Postpartum Hemorrhage.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body sodium (Na) levels must be maintained within a narrow range for the correct functioning of the organism (Na homeostasis). Na disorders include not only elevated levels of this solute (hypernatremia), as in diabetes insipidus, but also reduced levels (hyponatremia), as in cerebral salt wasting syndrome. The balance in body Na levels therefore requires a delicate equilibrium to be maintained between the ingestion and excretion of Na. Salt (NaCl) intake is processed by receptors in the tongue and digestive system, which transmit the information to the nucleus of the solitary tract via a neural pathway (chorda tympani/vagus nerves) and to circumventricular organs, including the subfornical organ and area postrema, via a humoral pathway (blood/cerebrospinal fluid). Circuits are formed that stimulate or inhibit homeostatic Na intake involving participation of the parabrachial nucleus, pre-locus coeruleus, medial tuberomammillary nuclei, median eminence, paraventricular and supraoptic nuclei, and other structures with reward properties such as the bed nucleus of the stria terminalis, central amygdala, and ventral tegmental area. Finally, the kidney uses neural signals (e.g., renal sympathetic nerves) and vascular (e.g., renal perfusion pressure) and humoral (e.g., renin-angiotensin-aldosterone system, cardiac natriuretic peptides, antidiuretic hormone, and oxytocin) factors to promote Na excretion or retention and thereby maintain extracellular fluid volume. All these intake and excretion processes are modulated by chemical messengers, many of which (e.g., aldosterone, angiotensin II, and oxytocin) have effects that are coordinated at peripheral and central level to ensure Na homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.