ArticleNutrients2023
Prognostic Nutritional Index as a Predictor of Mortality in 101,616 Patients Undergoing Hemodialysis.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of the geriatric nutritional risk index on long-term outcomes in patients undergoing hemodialysis: a meta-analysis of observational studies.Frontiers in nutrition · 2024Pooled it
- A Critical Reassessment of Inflammatory and Nutritional Indices (PNI, GNRI, SII, NLR, PLR) for Predicting Arteriovenous Fistula Maturation and Long-Term Patency: A 945-Patient Cohort.Journal of clinical medicine · 2026Article
- Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Inflammatory Biomarkers and Clinical Outcomes in Hospitalized Hemodialysis Patients with COVID-19: A Retrospective Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- The diagnostic value of prognostic nutritional ındex and controlling nutritional status score in differentiating retinal vein occlusion.International ophthalmology · 2026Article
- Systemic Immune-Inflammation Index and Prognostic Nutritional Index as Predictors of Renal Survival in Crescentic Glomerulonephritis.International journal of general medicine · 2026Article
- Associations of Geriatric Nutritional Risk Index and Prognostic Nutritional Index With All-Cause and Cardiovascular Mortality in DKD: NHANES 1999-2018.International journal of endocrinology · 2026Article
- Article
- Preoperative high-sensitivity C-reactive protein-to-albumin ratio predicts arteriovenous fistula failure in hemodialysis patients: a retrospective cohort study with landmark analysis.Frontiers in surgery · 2026Article
- Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease.Annals of medicine · 2025Article
- Increased dialysis symptom index burden in maintenance hemodialysis patients during the COVID-19 lockdown period.Annals of medicine · 2025Article
- Risk Factors for Complications and 90-Day Mortality After Percutaneous Endoscopic Gastrostomy: The Role of Nutritional and Inflammatory Markers.Medicina (Kaunas, Lithuania) · 2025Article
- Explainable machine learning models for predicting of protein-energy wasting in patients on maintenance haemodialysis.BMC nephrology · 2025Article
- Prognostic nutritional index, sarcopenia, and risk of mortality: a national population-based study.Nutrition & metabolism · 2025Article
- Intersecting Pathways of Inflammation, Oxidative Stress, and Atherogenesis in the Evaluation of CKD: Emerging Biomarkers PCSK9, EPHX2, AOPPs, and TBARSs.Life (Basel, Switzerland) · 2025Review
- Article
- Prognostic Nutritional Index Trajectories Predict Kidney Function in Kidney Transplant Recipients: A Latent Class Growth Model Study.Annals of transplantation · 2025Article
- Sex-Specific Impact of Inflammation and Nutritional Indices on AVF Blood Flow and Maturation: A Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Predictive values of four nutritional indices for adverse outcomes in patients with hypertension.Clinical and experimental nephrology · 2025Article
- One-Year Mortality After Percutaneous Endoscopic Gastrostomy: The Prognostic Role of Nutritional Biomarkers and Care Settings.Nutrients · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
High mortality in dialysis patients is linked to malnutrition and inflammation. Prognostic nutritional index (PNI), calculated from serum albumin level and total lymphocyte count, has been developed as a prognostic marker for cancer patients. We investigated the clinical utility of PNI in predicting mortality in patients undergoing hemodialysis. Thus, 101,616 patients who initiated hemodialysis in United States dialysis centers between 2007 and 2011 were included in this retrospective cohort study. Using the Cox regression model, we assessed the relationship between PNI and mortality. Further, the predictive value of PNI for one-year mortality was compared with that of its constituent using area under the receiver operating characteristic curve, net reclassification improvement, and integrated discrimination improvement. Higher PNI quartiles were incrementally associated with lower mortality; in patients with PNI values of 39.5−<43.1, 43.1−<46.6, and ≥46.6 (reference: PNI < 39.5), case-mix adjusted hazard ratios (95% confidence intervals) were 0.66 (0.64, 0.68), 0.49 (0.48, 0.51), and 0.36 (0.34, 0.37), respectively. PNI predicted mortality better than serum albumin level or total lymphocyte count alone. In the subgroup analysis, PNI performed well in predicting mortality in patients aged < 65 years. Our results indicate that PNI is a simple and practical prognostic marker in patients undergoing hemodialysis.
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