Evidence map›Paper›PMID 36678169›Full record

ArticleNutrients2023

Early-Life Gut Health Indicators and Reported Prevalence of Infant Functional Constipation by Healthcare Professionals.

Leilani Muhardi, Dianne J M Delsing, Irina Zakharova, Koen Huysentruyt, Sze-Yee Chong, Ruey Terng Ng, Andy Darma, Badriul Hegar, Mohammed Hasosah, Erick Toro-Monjaraz and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Nutrients · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 8 countries.

Leilani MuhardiFrieslandCampina AMEA, Singapore 039190, Singapore.ORCID 0000-0001-9987-2041
Dianne J M DelsingFrieslandCampina, 3818 LE Amersfoort, The Netherlands.
Irina ZakharovaDepartment of Pediatrics, Russian Medical Academy Continuous Professional Education of the Ministry of Health of Russian Federation, Moscow 125993, Russia.
Koen HuysentruytKidZ Health Castle, Department of Pediatric Gastroenterology, UZ Brussel, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.
Sze-Yee ChongDepartment of Pediatrics, Hospital Raja Permaisuri Bainun, Ipoh 30450, Malaysia.ORCID 0000-0002-2098-2270
Ruey Terng NgDepartment of Pediatrics, University of Malaya, Kuala Lumpur 50603, Malaysia.
Andy DarmaDepartment of Pediatrics, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Badriul HegarDepartment of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia.ORCID 0000-0002-5924-1664
Mohammed HasosahDepartment of Pediatric, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 14611, Saudi Arabia.ORCID 0000-0002-8434-2109
Erick Toro-MonjarazUnit of Physiology and Gastrointestinal Motility, Gastroenterology and Nutrition Department, National Institute of Pediatrics, Mexico City 04530, Mexico.
Merih CetinkayaDepartment of Neonatology, Health Sciences University, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey.ORCID 0000-0002-7344-8637
Chung-Mo ChowVirtus Medical Group, Hong Kong.
Marion M AwDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Urszula KudlaFrieslandCampina, 3818 LE Amersfoort, The Netherlands.
Louise Naz WestFrieslandCampina, 3818 LE Amersfoort, The Netherlands.
Yvan VandenplasKidZ Health Castle, Department of Pediatric Gastroenterology, UZ Brussel, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.ORCID 0000-0002-1862-8651
FrieslandCampina (Netherlands) · NLVrije Universiteit Brussel · BEAirlangga University · IDInstitut Penyelidikan Veterinar · MYKing Saud bin Abdulaziz University for Health Sciences · SANational University of Singapore · SGRussian Medical Academy of Continuous Professional Education · RUSağlık Bilimleri Üniversitesi · TRUniversity of Indonesia · IDUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A healthy gut during early childhood is important. However, it seems that there are no standard indicators used to assess it. Healthcare professionals (HCPs) were asked via an electronic survey question about gut health indicators (GHIs) for infants and toddlers, in addition to an estimated prevalence of infant's functional constipation (FC) and its management. HCPs from eight countries participated in the survey (Russia (66.0%, 1449), Indonesia (11.0%, 242), Malaysia (6.0%, 132), Mexico (5.7%, 125), KSA (5.1%, 113), Turkey (3.0%, 66), Hong Kong (2.2%, 49), and Singapore (1.0%, 23)). The 2199 participating respondents were further classified into three continents (Asia (20.2%), Europe (68.8%), and others (11.0%)). Most of them were pediatricians (80.3%), followed by pediatric gastroenterologists (7.0%), general practitioners (6.4%), and others (6.3%). The top three preferred GHIs were similar for infants and toddlers: an absence of gastrointestinal (GI) symptoms, effective digestion/absorption as assessed by normal growth, and a general feeling of well-being. The absence of GI-related infection was the least preferred indicator. Most of the respondents reported the prevalence of FC among infants was less than 5%, with the peak incidence between the ages of 3 and 6 months. The reported choices of intervention to manage FC in infants were a change to a specific nutritional solution from a standard formula (40.2%), parental reassurance (31.7%), and lactulose (17.0%). Conclusion: The HCPs in the eight countries preferred the absence of GI symptoms, normal growth for effective digestion and absorption, and general well-being as the gut health indicators in infants and toddlers. The reported prevalence of FC in infants was less than 5%.

Indexed as

ConstipationGastrointestinal DiseasesChild, PreschoolDelivery of Health CareHong KongHumansInfantPrevalencee-surveygut health indicatorshealthcare professionalsinfanttoddlers

Identifiers

PMID36678169
PMCPMC9862041
OpenAlexW4313827791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.