Evidence map›Paper›PMID 36678154›Full record

ArticleNutrients2023

Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.

Carles Lerin, María Carmen Collado, Elvira Isganaitis, Erland Arning, Brandi Wasek, Ellen W Demerath, David A Fields, Teodoro Bottiglieri

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Methionine metabolism, functions, and application in swine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Carles LerinEndocrinology Department, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.
María Carmen ColladoDepartment of Biotechnology, Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), 46980 Valencia, Spain.ORCID 0000-0002-6204-4864
Elvira IsganaitisResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Erland ArningCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Brandi WasekCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Ellen W DemerathDivision of Epidemiology and Community Health, The University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.
David A FieldsDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Teodoro BottiglieriCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.ORCID 0000-0002-4199-7551
Baylor Medical Center at Garland · USHospital Sant Joan de Déu Barcelona · ESInstituto de Agroquímica y Tecnología de Alimentos · ESJoslin Diabetes Center · USUniversity of Minnesota · USUniversity of Oklahoma Health Sciences Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Maternal Obesity, Milk Composition, and Infant GrowthR01HD080444 · NICHD · UNIVERSITY OF MINNESOTA · PI ELLEN W. DEMERATH, DAVID A FIELDS · 2014 to 2026
$6.4M
Milk-Omics: Systems Biology of Human Milk and Its Links to Maternal and Infant HealthR01HD109830 · NICHD · UNIVERSITY OF MINNESOTA · PI Ran Blekhman, ELLEN W. DEMERATH · 2022 to 2026
$3.5M
Pathways of Mother to Child Transmission of Metabolic RiskR00HD064793 · NICHD · JOSLIN DIABETES CENTER · PI ISGANAITIS, ELVIRA MARIE · 2013 to 2015
$734k
NICHD NIH HHS R00 HD064793NICHD NIH HHS R01 HD080444NICHD NIH HHS R01 HD109830NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

Breastfeeding is the gold standard for early nutrition. Metabolites from the one-carbon metabolism pool are crucial for infant development. The aim of this study is to compare the breast-milk one-carbon metabolic profile to other biofluids where these metabolites are present, including cord and adult blood plasma as well as cerebrospinal fluid. Breast milk (

Indexed as

Milk, HumanS-AdenosylmethionineAdultCarbonChildChromatography, LiquidFemaleHomocysteineHumansInfantMethionineRacemethionineS-AdenosylhomocysteineTandem Mass SpectrometryCarbonHomocysteineMethionineRacemethionineS-AdenosylhomocysteineS-Adenosylmethioninebreastfeedingbreast milkmilk formulaone-carbon metabolismS-adenosylmethionine

Identifiers

PMID36678154
PMCPMC9863976
OpenAlexW4313647124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.