Evidence map›Paper›PMID 36677918›Full record

ArticleMolecules (Basel, Switzerland)2023

Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products Extending the Shelf-Life in Non-Refrigerated Conditions.

Giuseppina Gullifa, Roberta Risoluti, Cristina Mazzoni, Laura Barone, Elena Papa, Alfredo Battistini, Rodrigo Martin Fraguas, Stefano Materazzi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  14. Effect of encapsulation technology andFrontiers in microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppina GullifaDepartment of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9252-8205
Roberta RisolutiDepartment of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.ORCID 0000-0002-6213-5387
Cristina MazzoniDepartment of Biology and Biotechnologies "C. Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy.ORCID 0000-0002-1504-6189
Laura BaroneDepartment of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.ORCID 0000-0002-2279-0272
Elena PapaDepartment of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.
Alfredo BattistiniConsiglio per la Ricerca in Agricoltura e l'Analisi dell'economia Agraria-Centro di Politiche e Bioeconomia, Via Pò 14, 00198 Rome, Italy.
Rodrigo Martin FraguasDepartment of Chemistry, Campus Varginha, University of José do Rosário Vellano-UNIFENAS, Alfenas 37130-000, Brazil.
Stefano MaterazziDepartment of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy.ORCID 0000-0002-8468-5291

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major challenge is to market new, multicomponent probiotic foods and supplements. Nevertheless, only a few products containing encapsulated probiotic cells can be found as non-refrigerated products. In this work, spray drying technology was investigated in order to produce an innovative nutraceutical formulation based on lactic acid bacteria (LAB), and was able to ensure a good storage stability of probiotics (no less than 109 CFU/cps) in non-refrigerated conditions. Probiotic-loaded microparticles from spray drying experiments were produced under different conditions and compared by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and the enumeration of the number of viable cells in order to identify the formulation exhibiting the most promising characteristics. Results from the dissolution test revealed that the optimized formulation provides a suitable amount of living cells after digestion of microparticles stored for 12 months at room temperature and confirmed that the microencapsulation process by spray drying ensures a good protection of probiotics for nutraceutical purposes.

Indexed as

ProbioticsSpray DryingBacteriaDairy ProductsHumansMicrobial Viabilitymicroencapsulationnutraceuticsprobioticsspray drying

Identifiers

PMID36677918
PMCPMC9862012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.