Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 3 institutions in 1 country.
Maria Laura De SciscioDepartment of Chemistry, University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-5523-0987
Alessandro Nicola NardiDepartment of Chemistry, University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-0959-1690
Giacomo ParisiCenter for Life Nano & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, IIT, 00185 Rome, Italy.ORCID 0000-0002-3064-0928
Giovanni BulfaroDepartment of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-5289-2969
Antonella CostanzoDepartment of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-9634-0063
Elena GugoleDepartment of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8622-3886
Cécile ExertierInstitute of Molecular Biology and Pathology, CNR c/o Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-7457-6895
Ida FredaDepartment of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-0756-9537
Carmelinda SavinoInstitute of Molecular Biology and Pathology, CNR c/o Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-1602-4838
Beatrice ValloneDepartment of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0003-0058-9049
Linda Celeste MontemiglioInstitute of Molecular Biology and Pathology, CNR c/o Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-4253-7493
Marco D'AbramoDepartment of Chemistry, University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6020-8581
Sapienza University of Rome · ITInstitute of Molecular Biology and Pathology · ITItalian Institute of Technology · IT
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affect OleP conformational equilibrium between the open and the closed-catalytic competent-forms. Our data clearly show that at high-ionic strength conditions, the closed form is favored, and, very interestingly, different mechanisms, depending on the chemistry of the cations, can be used to rationalize such an effect.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP. · full record | OpenQuestion