Evidence map›Paper›PMID 36677813›Full record

ArticleMolecules (Basel, Switzerland)2023

In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents.

Goutam Mondal, Olivia R Dale, Yan-Hong Wang, Shabana I Khan, Ikhlas A Khan, Charles R Yates

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Goutam MondalNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Olivia R DaleNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Yan-Hong WangNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Shabana I KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Ikhlas A KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Charles R YatesNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
University of Mississippi · US

Funding

doTerra N/AUniversity of Mississippi N/A
6 · The paper itself

Abstract

The application of essential oils has historically been limited to topical (massage therapy) and inhalational (aromatherapy) routes of administration. More recently, however, evaluation of the therapeutic effects of essential oils has expanded to include the oral route of administration, which increases the herb-drug interaction potential. The purpose of this study was to evaluate the herb-drug interaction potential of lavender essential oil and two of its primary phytoactive constituents, namely linalool and linalyl acetate. The metabolic stability of linalool and linalyl acetate was determined in human liver microsomes (HLM) and S9 fractions by quantitative analysis using UPLC-MS/MS system. Linalool was metabolically unstable in HLM and S9 fractions with an intrinsic clearance of 31.28 mL·min

Indexed as

LavandulaOils, VolatileAcyclic MonoterpenesChromatography, LiquidCytochrome P-450 CYP3AHumansMonoterpenesPlant OilsTandem Mass SpectrometryAcyclic MonoterpenesCytochrome P-450 CYP3Alavender oillinaloollinalyl acetateMonoterpenesOils, VolatilePlant Oilsessential oillinaloolmetabolism

Identifiers

PMID36677813
PMCPMC9862203
OpenAlexW4315795615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.