Evidence map›Paper›PMID 36677751›Full record

ArticleMolecules (Basel, Switzerland)2023

Xing Wang, Chen Zhang, Ryma Madji, Camille Voros, Serge Mazères, Christian Bijani, Céline Deraeve, Olivier Cuvillier, Heinz Gornitzka, Marie-Lise Maddelein and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xing WangCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Chen ZhangCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Ryma MadjiCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Camille VorosCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Serge MazèresInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.ORCID 0000-0002-0263-634X
Christian BijaniCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Céline DeraeveCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.ORCID 0000-0001-6435-5765
Olivier CuvillierCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.ORCID 0000-0003-3346-375X
Heinz GornitzkaCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.ORCID 0000-0002-8838-5907
Marie-Lise MaddeleinCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Catherine HemmertCoordination Chemistry Laboratory of the National Centre for Scientific Research (LCC-CNRS), University of Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), 31077 Toulouse, France.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of seven novel iridium complexes were synthetized and characterized as potential photosensitizers for photodynamic therapy (PDT) applications. Among them, four complexes were evaluated in vitro for their anti-proliferative activity with and without irradiation on a panel of five cancer cell lines, namely PC-3 (prostate cancer), T24 (bladder cancer), MCF7 (breast cancer), A549 (lung cancer) and HeLa (cervix cancer), and two non-cancerous cell models (NIH-3T3 fibroblasts and MC3T3 osteoblasts). After irradiation at 458 nm, all tested complexes showed a strong selectivity against cancer cells, with a selectivity index (SI) ranging from 8 to 34 compared with non-cancerous cells. The cytotoxic effect of all these complexes was found to be independent of the anti-apoptotic protein Bcl-xL. The compound exhibiting the best selectivity, complex

Indexed as

NeoplasmsPhotochemotherapyApoptosisCell Line, TumorHumansIridiumMethanePhotosensitizing AgentscarbeneIridiumMethanePhotosensitizing AgentsapoptosisBcl-xLcaspasecell deathiridiumluminescenceN-heterocyclic carbenePARPphotodynamic therapy

Identifiers

PMID36677751
PMCPMC9861386
OpenAlexW4309980432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.