Evidence map›Paper›PMID 36677633›Full record

ArticleMolecules (Basel, Switzerland)2023

Drug Repurposing to Inhibit Histamine

Elvia Mera Jiménez, Teresa Żołek, Paola Gabriela Hernández Perez, Rene Miranda Ruvalcaba, María Inés Nicolás-Vázquez, Maricarmen Hernández-Rodríguez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurodegenerative Disease: From Molecular Basis to Therapy, 2nd Edition.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elvia Mera JiménezLaboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.
Teresa ŻołekDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-091 Warsaw, Poland.ORCID 0000-0002-6781-0329
Paola Gabriela Hernández PerezLaboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.
Rene Miranda RuvalcabaQuímica Inorgánica-Orgánica del Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán Campo 1, UNAM. Av. Primero de Mayo S/N, Sta María Guadalupe las Torres, Cuautitlán Izcalli 54740, Mexico.ORCID 0000-0002-1979-5590
María Inés Nicolás-VázquezQuímica Inorgánica-Orgánica del Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán Campo 1, UNAM. Av. Primero de Mayo S/N, Sta María Guadalupe las Torres, Cuautitlán Izcalli 54740, Mexico.
Maricarmen Hernández-RodríguezLaboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0001-9371-1095
Instituto Politécnico Nacional · MXUniversidad de Cuautitlán Izcalli · MXMedical University of Warsaw · PL

Funding

Consejo Nacional de Ciencia y Tecnología 320862Instituto Politécnico Nacional 20227029Instituto Politécnico Nacional SIP20221071Instituto Politécnico Nacional SIP20221072National Autonomous University of Mexico IN212421
6 · The paper itself

Abstract

Lower activity of the histaminergic system is associated with neurological disorders, including Alzheimer's disease (AD). Thus, the enhancement of histaminergic neurotransmission by inhibition of histamine

Indexed as

HistamineTransferasesDihydroergotamineDrug RepositioningHistamine N-MethyltransferaseMolecular Docking SimulationVilazodone HydrochlorideDihydroergotamineHistamineHistamine N-MethyltransferaseTransferasesVilazodone Hydrochloridecomputational studiesdrug repurposinghistamine N-methyl transferasemolecular docking studiesmolecular dynamics simulations

Identifiers

PMID36677633
PMCPMC9867436
OpenAlexW4313646876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.