Evidence map›Paper›PMID 36677621›Full record

ArticleMolecules (Basel, Switzerland)2023

In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents.

Yi-Fong Chen, Bashir Lawal, Li-Jiau Huang, Sheng-Chu Kuo, Maryam Rachmawati Sumitra, Ntlotlang Mokgautsi, Hung-Yun Lin, Hsu-Shan Huang

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Current medicinal chemistry · 2025
    Article
  3. Review
  4. Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi-Fong ChenGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-9545-1191
Bashir LawalUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.ORCID 0000-0003-0676-5875
Li-Jiau HuangPh.D. Program for Cancer Biology and Drug Discovery, College of Medicine, China Medical University and Academia Sinica, Taichung 40402, Taiwan.
Sheng-Chu KuoPh.D. Program for Cancer Biology and Drug Discovery, College of Medicine, China Medical University and Academia Sinica, Taichung 40402, Taiwan.
Maryam Rachmawati SumitraGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Ntlotlang MokgautsiGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-2076-9768
Hung-Yun LinGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-2824-6419
Hsu-Shan HuangGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-6193-5182

Funding

Ministry of Science and Technology, Taiwan MOST111-2314-B-038-122National Science and Technology Council, Taiwan NSTC111-2314-B-038-017National Science and Technology Council, Taiwan NSTC111-2811-B-038-025National Science Council of the Republic of China NSC 101-2320-B-039-009-MY3National Science Council of the Republic of China NSC 95-2320-B-039-011-MY3
6 · The paper itself

Abstract

Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic agents, and we adopted the drug design concept of scaffold hopping to replace the 2-aromatic ring of 2-PQs with a 4-aromatic ring, representing 4-phenyl-2-quinolones (4-PQs). The 4-PQ compounds, whose structural backbones also mimic analogs of podophyllotoxin (PPT), maybe a new class of anticancer drugs with simplified PPT structures. In addition, 4-PQs are a new generation of anticancer lead compounds as apoptosis stimulators. On the other hand, previous studies showed that 4-arylcoumarin derivatives with 5-, 6-, and 7-methoxy substitutions displayed remarkable anticancer activities. Therefore, we further synthesized a series of 5-, 6-, and 7-methoxy-substituted 4-PQ derivatives (

Indexed as

Antineoplastic Agents4-QuinolonesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHydroxyquinolinesMolecular Docking SimulationMolecular StructurePodophyllotoxinQuinolonesStructure-Activity Relationship4-QuinolonesAntineoplastic AgentscarbostyrilHydroxyquinolinesPodophyllotoxinQuinolones4-phenyl-2-quinolone (4-PQ)anticancerantimitotic agentstructure–activity relationship (SAR)tubulin

Identifiers

PMID36677621
PMCPMC9861105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.