Evidence map›Paper›PMID 36677548›Full record

ArticleMolecules (Basel, Switzerland)2023

Genome Investigation and Functional Annotation of

Tariq Aziz, Muhammad Naveed, Syeda Izma Makhdoom, Urooj Ali, Muhammad Saad Mughal, Abid Sarwar, Ayaz Ali Khan, Yang Zhennai, Manal Y Sameeh, Anas S Dablool and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  20. Effects of the Exopolysaccharide fromFoods (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Tariq AzizBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-0905-8076
Muhammad NaveedDepartment of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.
Syeda Izma MakhdoomDepartment of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.ORCID 0000-0002-9978-1067
Urooj AliDepartment of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.ORCID 0000-0002-6640-752X
Muhammad Saad MughalDepartment of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.ORCID 0000-0001-7461-6826
Abid SarwarBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-2105-7201
Ayaz Ali KhanDepartment of Biotechnology, University of Malakand, Chakdara 18800, Pakistan.ORCID 0000-0002-9274-2620
Yang ZhennaiBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.
Manal Y SameehChemistry Department, Faculty of Applied Sciences, Al-Leith University College, Umm Al-Qura University, Makkah 24831, Saudi Arabia.
Anas S DabloolDepartment of Public Health, Health Sciences College Al-Leith, Umm Al-Qura University, Makkah al-Mukarramah 24382, Saudi Arabia.ORCID 0000-0001-6744-6259
Amnah A AlharbiDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-9879-9508
Muhammad ShahzadInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan.ORCID 0000-0001-6565-1777
Abdulhakeem S AlamriDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-3174-0434
Majid AlhomraniDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0001-9798-0962
University of Central Punjab · PKBeijing Technology and Business University · CNTaif University · SAUmm al-Qura University · SAKhyber Medical University · PKUniversity of Malakand · PKUniversity of Tabuk · SA

Funding

National Key Research and Development Program of China 2017YFE0131800National Natural Science Foundation of China 31871823
6 · The paper itself

Abstract

All nutrient-rich feed and food environments, as well as animal and human mucosae, include lactic acid bacteria known as Lactobacillus plantarum. This study reveals an advanced analysis to study the interaction of probiotics with the gastrointestinal environment, irritable bowel disease, and immune responses along with the analysis of the secondary metabolites’ characteristics of Lp YW11. Whole genome sequencing of Lp YW11 revealed 2297 genes and 1078 functional categories of which 223 relate to carbohydrate metabolism, 21 against stress response, and the remaining 834 are involved in different cellular and metabolic pathways. Moreover, it was found that Lp YW11 consists of carbohydrate-active enzymes, which mainly contribute to 37 glycoside hydrolase and 28 glycosyltransferase enzyme coding genes. The probiotics obtained from the BACTIBASE database (streptin and Ruminococcin-A bacteriocins) were docked with virulent proteins (cdt, spvB, stxB, and ymt) of Salmonella, Shigella, Campylobacter, and Yersinia, respectively. These bacteria are the main pathogenic gut microbes that play a key role in causing various gastrointestinal diseases. The molecular docking, dynamics, and immune simulation analysis in this study predicted streptin and Ruminococcin-A as potent nutritive bacteriocins against gut symbiotic pathogens.

Indexed as

BacteriocinsLactiplantibacillus plantarumProbioticsAnimalsBacteriaHumansMolecular Docking SimulationBacteriocinsstreptingut microbiotaLP YW11nutritive bacteriocinruminococcinstreptinwhole genome

Identifiers

PMID36677548
PMCPMC9862464
OpenAlexW4313500513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.