Evidence map›Paper›PMID 36677387›Full record

ReviewMicroorganisms2022

Journey of the Probiotic Bacteria: Survival of the Fittest.

Allyson Andrade Mendonça, Walter de Paula Pinto-Neto, Giselle Alves da Paixão, Dayane da Silva Santos, Marcos Antonio De Morais, Rafael Barros De Souza

Abstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Extracellular vesicles as indicators of environmental stress response inExtracellular vesicles and circulating nucleic acids · 2026
    Article
  9. Probiotic Development Strategy Centered on Stability and Regulatory Considerations.Comprehensive reviews in food science and food safety · 2026
    Review
  10. Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026
    Review
  11. Application ofFoods (Basel, Switzerland) · 2025
    Review
  12. Comparative Analyses ofMicroorganisms · 2025
    Article
  13. Review
  14. Probiotic Dairy Innovations: Exploring Buffalo Milk Potential for Food Product Development.Comprehensive reviews in food science and food safety · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Allyson Andrade MendonçaLaboratory of Microbial Genetics, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-4977-6307
Walter de Paula Pinto-NetoLaboratory of Microbial Genetics, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-4222-7153
Giselle Alves da PaixãoLaboratory of Microbial Metabolism, Institute of Biological Sciences, University of Pernambuco, Recife 50100-130, Brazil.
Dayane da Silva SantosLaboratory of Microbial Genetics, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Marcos Antonio De MoraisLaboratory of Microbial Genetics, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-9727-0300
Rafael Barros De SouzaLaboratory of Microbial Metabolism, Institute of Biological Sciences, University of Pernambuco, Recife 50100-130, Brazil.ORCID 0000-0001-7462-7541

Funding

Fundação de Amparo à Ciência e Tecnologia de Pernambuco APQ-0434-2.12/20
6 · The paper itself

Abstract

This review aims to bring a more general view of the technological and biological challenges regarding production and use of probiotic bacteria in promoting human health. After a brief description of the current concepts, the challenges for the production at an industrial level are presented from the physiology of the central metabolism to the ability to face the main forms of stress in the industrial process. Once produced, these cells are processed to be commercialized in suspension or dried forms or added to food matrices. At this stage, the maintenance of cell viability and vitality is of paramount for the quality of the product. Powder products requires the development of strategies that ensure the integrity of components and cellular functions that allow complete recovery of cells at the time of consumption. Finally, once consumed, probiotic cells must face a very powerful set of physicochemical mechanisms within the body, which include enzymes, antibacterial molecules and sudden changes in pH. Understanding the action of these agents and the induction of cellular tolerance mechanisms is fundamental for the selection of increasingly efficient strains in order to survive from production to colonization of the intestinal tract and to promote the desired health benefits.

Indexed as

acid stressatomisationcarbon balancecentral carbon pathwaystress tolerance

Identifiers

PMID36677387
PMCPMC9861974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.