Evidence map›Paper›PMID 36677259›Full record

ArticleMicromachines2023

An Amperometric Biomedical Sensor for the Determination of Homocysteine Using Gold Nanoparticles and Acetylene Black-Dihexadecyl Phosphate-Modified Glassy Carbon Electrode.

Chunnan Zhu, Jingfang Zhang, Shunrun Zhang, Chao Liu, Xiaojun Liu, Jian Jin, Dongyun Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chunnan ZhuCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Jingfang ZhangCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Shunrun ZhangCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Chao LiuCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Xiaojun LiuCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Jian JinThe First Hospital of Wuhan, Wuhan 430022, China.
Dongyun ZhengCollege of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China.
Minzu University of China · CNWuhan No.1 Hospital · CN

Funding

Fundamental Research Funds for the Central Universities, South-Central Minzu University CZQ21025, CZQ22007, CPT22022 and CZY20006National Natural Science Foundation of China 61501526, 21804146 and 22004134Natural Science Foundation of Hubei Province 2020CFB313Opening Foundation of Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment PJS140012101
6 · The paper itself

Abstract

A novel nanocomposite film composed of gold nanoparticles and acetylene black-dihexadecyl phosphate was fabricated and modified on the surface of a glassy carbon electrode through a simple and controllable dropping and electropolymerization method. The nanocomposite film electrode showed a good electrocatalytic response to the oxidation of homocysteine and can work as an amperometric biomedical sensor for homocysteine. With the aid of scanning electron microscopy, energy dispersive X-ray technology and electrochemical impedance spectroscopy, the sensing interface was characterized, and the sensing mechanism was discussed. Under optimal conditions, the oxidation peak current of homocysteine was linearly increased with its concentration in the range of 3.0 µmol/L~1.0 mmol/L, and a sensitivity of 18 nA/(μmol/L) was obtained. Furthermore, the detection limit was determined as 0.6 µmol/L, and the response time was detected as 3 s. Applying the nanocomposite film electrode for monitoring the homocysteine in human blood serum, the results were satisfactory.

Indexed as

acetylene blackdetectiondihexadecyl phosphateglassy carbon electrodegold nanoparticleshomocysteine

Identifiers

PMID36677259
PMCPMC9865262
OpenAlexW4316040050

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.