Evidence map›Paper›PMID 36676717›Full record

ArticleMedicina (Kaunas, Lithuania)2022

Takotsubo Syndrome Occurring after mRNA COVID-19 Vaccination in a Patient with Graves' Disease.

Yen-Chi Chen, Gen-Min Lin, Eiki Takimoto, Chin-Sheng Lin, Wen-Yu Lin, Chun-Hsien Wu, Chia-Luen Huang, Cheng-Chung Cheng, Shu-Meng Cheng, Shih-Hua Lin and 2 more

Abstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Aberrant ICA in the middle ear.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yen-Chi ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.ORCID 0000-0003-0898-0544
Gen-Min LinDepartment of Medicine, Hualien Armed Forces General Hospital, Hualien City 97144, Taiwan.ORCID 0000-0002-5509-1056
Eiki TakimotoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Chin-Sheng LinDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.ORCID 0000-0002-5167-8327
Wen-Yu LinDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Chun-Hsien WuDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Chia-Luen HuangDivision of Endocrinology and Metabolism, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.ORCID 0000-0003-0717-0689
Cheng-Chung ChengDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Shu-Meng ChengDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Shih-Hua LinDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Issei KomuroDepartment of Cardiovascular Medicine, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Pang-Yen LiuDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.ORCID 0000-0002-3318-9757

Funding

Tri-Service General Hospital TSGH-PH_E-111017 (PYL)
6 · The paper itself

Abstract

Cardiovascular events such as myocarditis following mRNA COVID-19 vaccination are increasing. We present a 67-year-old postmenopausal woman with Takotsubo Syndrome and Graves' disease after mRNA COVID-19 vaccination. She developed chest pain and shortness of breath one week after vaccination. An electrocardiogram revealed ST elevation in the precordial leads. Coronary angiography revealed the absence of obstructive coronary artery disease, and the left ventriculography showed a typical feature with apical ballooning. Laboratory workup showed the elevation of free T4 and thyrotropin receptor antibodies. It was presumed that Takotsubo Syndrome and Graves' disease were probably related to the COVID-19 mRNA vaccination. The patient was treated with low-dose bisoprolol, diuretics, carbimazole, and steroid and discharged uneventfully. The mRNA COVID-19 vaccination is still safe and effective to defend against COVID-19 pandemic. However, clinicians should be aware of the possible cardiovascular adverse events other than myocarditis following vaccination.

Indexed as

COVID-19Graves DiseaseMyocarditisTakotsubo CardiomyopathyAgedCOVID-19 VaccinesFemaleHumansPandemicsCOVID-19 Vaccinesadverse effectsCOVID-19femaleGraves’ diseaseModerna COVID-19 vaccineTakotsubo syndrome

Identifiers

PMID36676717
PMCPMC9861603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.