Evidence map›Paper›PMID 36676067›Full record

ArticleLife (Basel, Switzerland)2022

Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments.

Minali Prasad, Jia Xu, Joshua S Agranat, Weiming Xia, Sarah Daley, Steven Ness, Xuejing Chen, Nicole H Siegel, Thor D Stein, Jaeyoon Chung and 1 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Minali PrasadDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0003-0596-1903
Jia XuDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0002-0019-9502
Joshua S AgranatDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0001-5310-0353
Weiming XiaDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Sarah DaleyDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Steven NessDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.
Xuejing ChenDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0001-6827-0152
Nicole H SiegelDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.ORCID 0000-0002-3523-8225
Thor D SteinLaboratory Medicine, Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA.
Jaeyoon ChungDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.ORCID 0000-0002-6431-9454
Manju L SubramanianDepartment of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.
Boston University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to characterize the inflammatory cytokine profile in rhegmatogenous retinal detachments (RRDs) compared to surgical controls. Vitreous humor was collected from patients undergoing vitrectomy for RRD and noninflammatory vitreoretinal diseases. A quantitative immunoassay was used to measure the levels of 36 cytokine markers. Linear regression analysis with the duration of detachment as the predictor and log-transformed cytokine levels as the outcome was conducted for normally distributed cytokines as determined by the Shapiro-Wilk test. The analysis was adjusted for age, sex, and race. The Kruskal-Wallis test was used for cytokines not normally distributed. Twenty-seven RRD cases and thirteen control cases were studied. Between all RRDs and controls, fibroblast growth factor 2 (FGF2) (

Indexed as

fibroblast growth factorinducible protein-10interleukin 6interleukin 8macrophage inflammatory protein-1 betamonocyte chemoattractant protein-1neuroinflammatory markersrhegmatogenous retinal detachment

Identifiers

PMID36676067
PMCPMC9862737
OpenAlexW4313471555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.