Evidence map›Paper›PMID 36675942›Full record

ReviewJournal of fungi (Basel, Switzerland)2023

More than Just Protein Degradation: The Regulatory Roles and Moonlighting Functions of Extracellular Proteases Produced by Fungi Pathogenic for Humans.

Dorota Satala, Grazyna Bras, Andrzej Kozik, Maria Rapala-Kozik, Justyna Karkowska-Kuleta

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Differential Thigmotropic Capacities Among Fusarial Isolates:Journal of fungi (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Review
  6. Decoding the rhizosphere microbiome againstFrontiers in microbiomes · 2026
    Review
  7. Article
  8. Clinical and Molecular Advances on the Black YeastInternational journal of molecular sciences · 2025
    Review
  9. SUB6 Subtilisin is Involved During the Initial Adhesion ofJID innovations : skin science from molecules to population health · 2025
    Article
  10. Article
  11. Unraveling the pathogenomics ofFrontiers in microbiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Moonlighting Proteins: Diverse Functions Found in Fungi.Journal of fungi (Basel, Switzerland) · 2023
    Review
  17. Journal of fungi (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dorota SatalaDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.ORCID 0000-0002-6233-6680
Grazyna BrasDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Andrzej KozikDepartment of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.ORCID 0000-0002-4935-4112
Maria Rapala-KozikDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.ORCID 0000-0002-3225-7391
Justyna Karkowska-KuletaDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.ORCID 0000-0001-6070-6919
Jagiellonian University · PL

Funding

National Science Center 2021/43/D/NZ6/01464 ; 2020/39/D/NZ6/00854
6 · The paper itself

Abstract

Extracellular proteases belong to the main virulence factors of pathogenic fungi. Their proteolytic activities plays a crucial role in the acquisition of nutrients from the external environment, destroying host barriers and defenses, and disrupting homeostasis in the human body, e.g., by affecting the functions of plasma proteolytic cascades, and playing sophisticated regulatory roles in various processes. Interestingly, some proteases belong to the group of moonlighting proteins, i.e., they have additional functions that contribute to successful host colonization and infection development, but they are not directly related to proteolysis. In this review, we describe examples of such multitasking of extracellular proteases that have been reported for medically important pathogenic fungi of the

Indexed as

allergensAspergillusCandidadermatophytesproteinasesSapyapsins

Identifiers

PMID36675942
PMCPMC9865821
OpenAlexW4316465142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.