ArticleJournal of personalized medicine2022
Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05992974 (To Identify Urinary Biomarkers in the First Trimester Associated With Gestational Diabetes Mellitus [GDM] and Achieve Early Diagnosis of GDM Using Urinary Proteomic Analysis), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
To Identify Urinary Biomarkers in the First Trimester Associated With Gestational Diabetes Mellitus [GDM] and Achieve Early Diagnosis of GDM Using Urinary Proteomic Analysis: An Observational Study
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- [Early detection of Insuline Resistence in Pregnant Women].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- The Association Between Measures of Prepregnancy Insulin Resistance and Sensitivity with Subsequent Risk of Gestational Diabetes.Journal of the Endocrine Society · 2026Article
- Gestational Diabetes Mellitus and Biomarker Profiles: A BMI-Stratified Analysis of Gremlin 1 and BMP 4-A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Early-pregnancy trunk phase angle derived from bioelectrical impedance analysis for the prediction of gestational diabetes mellitus.Frontiers in endocrinology · 2026Article
- Association between insulin resistance trajectories and perinatal complications: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Advances in gestational diabetes mellitus screening: Emerging trends and future directions.World journal of diabetes · 2025Review
- Evaluating the Predictive Value of HOMA-IR in Gestational Diabetes: A Case-Control Study from Romania.Diagnostics (Basel, Switzerland) · 2025Article
- Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus.Life (Basel, Switzerland) · 2025Article
- PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes.Reproduction (Cambridge, England) · 2025Review
- Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization.Cardiovascular diabetology · 2025Article
- Machine learning based model for the early detection of Gestational Diabetes Mellitus.BMC medical informatics and decision making · 2025Article
- Metabolic and Immune Parameters in Pregnant Women with Impaired Glucose Metabolism-A Pilot Study.Metabolites · 2024Article
- Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study.Endocrine · 2024Article
- Serum progesterone, glycosylated hemoglobin and insulin levels with the risk of premature rupture of membranes in gestational diabetes mellitus.Clinics (Sao Paulo, Brazil) · 2024Article
- A Simplified Screening Model to Predict the Risk of Gestational Diabetes Mellitus in Pregnant Chinese Women.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- The yield of early-pregnancy homeostasis of model assessment -insulin resistance (HOMA-IR) for predicting gestational diabetes mellitus in different body mass index and age groups.BMC pregnancy and childbirth · 2023Article
- Assessment of serum biotin levels and its association with blood glucose in gestational diabetes mellitus.European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Prediction Models for Gestational Diabetes Mellitus: Diagnostic Utility of Clinical and Biochemical Markers.Indian journal of endocrinology and metabolismArticle
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
Abstract
Objective: To investigate the ability of homeostasis model assessment of insulin resistance (HOMA-IR) in early pregnancy for predicting gestational diabetes mellitus (GDM) in Chinese women with different first-trimester body mass index (FT-BMI) values. Methods: Baseline characteristics and laboratory tests were collected at the first prenatal visit (6−12 weeks of gestation). GDM was diagnosed by a 75 g oral glucose tolerance test (OGTT) at 24−28 weeks of gestation. Partial correlation analysis and binary logistic regression were applied to identify the association between HOMA-IR and GDM. The cutoff points for predicting GDM were estimated using receiver operating characteristic (ROC) curve analysis. Results: Of the total of 1343 women, 300 (22.34%) were diagnosed with GDM in the 24−28 weeks of gestation. Partial correlation analysis and binary logistic regression verified HOMA-IR as a significant risk factor for GDM in the normal weight subgroup (FT-BMI < 24 kg/m2) (adjusted OR 2.941 [95% CI 2.153, 4.016], P < 0.001), overweight subgroup (24.0 kg/m2 ≤ FT-BMI < 28.0 kg/m2) (adjusted OR 3.188 [95% CI 2.011, 5.055], P < 0.001), and obese subgroup (FT-BMI ≥ 28.0 kg/m2) (adjusted OR 9.415 [95% CI 1.712, 51.770], p = 0.01). The cutoff values of HOMA-IR were 1.52 (area under the curve (AUC) 0.733, 95% CI 0.701−0.765, p < 0.001) for all participants, 1.43 (AUC 0.691, 95% CI 0.651−0.730, p < 0.001) for normal weight women, 2.27 (AUC 0.760, 95% CI 0.703−0.818, p < 0.001) for overweight women, and 2.31 (AUC 0.801, 95% CI 0.696−0.907, p < 0.001) for obese women. Conclusions: Increased HOMA-IR in early pregnancy is a risk factor for GDM, and HOMA-IR can be affected by body weight. The cutoff value of HOMA-IR to predict GDM should be distinguished by different FT-BMI values.
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