Evidence map›Paper›PMID 36675555›Full record

ArticleJournal of clinical medicine2023

SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes.

Luigi De Maria, Stefania Sponselli, Antonio Caputi, Pasquale Stefanizzi, Antonella Pipoli, Gianmarco Giannelli, Giuseppe Delvecchio, Silvio Tafuri, Francesco Inchingolo, Giovanni Migliore and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Luigi De MariaInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-0553-5309
Stefania SponselliInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Antonio CaputiInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-8872-6786
Pasquale StefanizziInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Antonella PipoliInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-1800-0872
Gianmarco GiannelliInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-8234-2690
Giuseppe DelvecchioInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Silvio TafuriInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-4194-0210
Francesco InchingoloInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Giovanni MiglioreGeneral Direction, Policlinico Regional Hospital of Bari, 70124 Bari, Italy.
Francesco Paolo BianchiInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-9659-0193
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-3811-2791
Luigi VimercatiInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-4072-2871
University of Bari Aldo Moro · ITStony Brook University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital.

methodsA retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW's health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary.

resultsThe cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%;

conclusionsOur results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced.

Indexed as

breakthrough infectionsCOVID-19health workersSARS-CoV-2 vaccination

Identifiers

PMID36675555
PMCPMC9864312
OpenAlexW4316038772

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.