Evidence map›Paper›PMID 36675533›Full record

ReviewJournal of clinical medicine2023

Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury.

Saugata Dutta, Yin Zhu, Yohan Han, Sultan Almuntashiri, Xiaoyun Wang, Duo Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Saugata DuttaClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-4377-5706
Yin ZhuClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Yohan HanClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Sultan AlmuntashiriClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-4353-6043
Xiaoyun WangClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0002-9900-740X
Duo ZhangClinical and Experimental Therapeutics, Charlie Norwood VA Medical Center, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-0361-4174
University of Georgia · US

Funding

MMP-8 Deficiency Improves Host Responses to Influenza Viral InfectionsF32HL147437 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2019 to 2021
$205k
Mechanistic Insights of TIMP-1 in Influenza Virus InfectionR03AI169063 · NIAID · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2022 to 2023
$151k
NHLBI NIH HHS F32 HL147437NIAID NIH HHS R03 AI169063NIH HHS NIH/NHLBI R00 HL141685NIH HHS NIH/NIAID R03AI169063
6 · The paper itself

Abstract

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent an acute stage of lung inflammation where the alveolar epithelium loses its functionality. ALI has a devastating impact on the population as it not only has a high rate of incidence, but also has high rates of morbidity and mortality. Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts longer than 200 nucleotides. Growing evidence has shown that lncRNAs have a decisive role in the pathogenesis of ALI. LncRNAs can either promote or hinder the development of ALI in various cell types in the lungs. Mechanistically, current studies have found that lncRNAs play crucial roles in the pathogenesis of ALI via the regulation of small RNAs (e.g., microRNAs) or downstream proteins. Undoubtedly, lncRNAs not only have the potential to reveal the underlying mechanisms of ALI pathogenesis but also serve as diagnostic and therapeutic targets for the therapy of ALI.

Indexed as

acute respiratory distress syndromeinflammationnoncoding RNApulmonary disease

Identifiers

PMID36675533
PMCPMC9861694
OpenAlexW4315786412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.