Evidence map›Paper›PMID 36675528›Full record

ArticleJournal of clinical medicine2023

A Systems Biology Approach for Addressing Cisplatin Resistance in Non-Small Cell Lung Cancer.

Sravani Ramisetty, Prakash Kulkarni, Supriyo Bhattacharya, Arin Nam, Sharad S Singhal, Linlin Guo, Tamara Mirzapoiazova, Bolot Mambetsariev, Sandeep Mittan, Jyoti Malhotra and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. mHereditas · 2025
    Article
  5. Article
  6. Article
  7. Short-chain fatty acids in cancer pathogenesis.Cancer metastasis reviews · 2023
    Review
  8. Article
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  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Sravani RamisettyDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Prakash KulkarniDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Supriyo BhattacharyaTranslational Bioinformatics, Center for Informatics, Department of Computational and Quantitative Medicine, City of Hope National Medical Center, 1500 Duarte Rd, Duarte, CA 91010, USA.ORCID 0000-0003-0483-2149
Arin NamDepartment of Pathology, University of California, La Jolla, San Diego, CA 92093, USA.
Sharad S SinghalDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Linlin GuoDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Tamara MirzapoiazovaDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Bolot MambetsarievDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Sandeep MittanMontefiore Medical Center, The University Hospital for Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Jyoti MalhotraDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1000 FivePoint, Irvine, CA 92618, USA.
Evan PisickCancer Treatment Centers of America (CTCA) Chicago, 2520 Elisha Avenue, Zion, IL 60099, USA.
Shanmuga SubbiahDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1250 S. Sunset Ave., Suite 303, West Covina, CA 91790, USA.
Swapnil RajurkarDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1100 San Bernardino Road, Suite 1100, Upland, CA 91786, USA.
Erminia MassarelliDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-7798-7286
Ravi SalgiaDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-9643-7626
Atish MohantyDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0003-1464-3165
City Of Hope National Medical Center · USAlbert Einstein College of Medicine · USCancer Treatment Centers of America · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translational research in medicine, defined as the transfer of knowledge and discovery from the basic sciences to the clinic, is typically achieved through interactions between members across scientific disciplines to overcome the traditional silos within the community. Thus, translational medicine underscores 'Team Medicine', the partnership between basic science researchers and clinicians focused on addressing a specific goal in medicine. Here, we highlight this concept from a City of Hope perspective. Using cisplatin resistance in non-small cell lung cancer (NSCLC) as a paradigm, we describe how basic research scientists, clinical research scientists, and medical oncologists, in true 'Team Science' spirit, addressed cisplatin resistance in NSCLC and identified a previously approved compound that is able to alleviate cisplatin resistance in NSCLC. Furthermore, we discuss how a 'Team Medicine' approach can help to elucidate the mechanisms of innate and acquired resistance in NSCLC and develop alternative strategies to overcome drug resistance.

Indexed as

cisplatindrug resistancegroup behaviorIDPsmathematical modelingnon-small cell lung cancerphenotype switching

Identifiers

PMID36675528
PMCPMC9861808
OpenAlexW4315700868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.