Evidence map›Paper›PMID 36675507›Full record

ArticleJournal of clinical medicine2023

Andrea Duminuco, Salvatore Scarso, Alessandra Cupri, Nunziatina Laura Parrinello, Loredana Villari, Grazia Scuderi, Giuliana Giunta, Salvatore Leotta, Giulio Antonio Milone, Giulia Giuffrida and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Emergencies in Hematology: Why, When and How I Treat?Journal of clinical medicine · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Polycythemia Vera: Barriers to and Strategies for Optimal Management.Blood and lymphatic cancer : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Andrea DuminucoDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.ORCID 0000-0002-9510-4755
Salvatore ScarsoNational Center for Global Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-2956-8997
Alessandra CupriDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.
Nunziatina Laura ParrinelloDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.
Loredana VillariUnit of Pathological Anatomy, A.O.U. Policlinico "G.Rodolico-San Marco", Viale Carlo Azeglio Ciampi, 95123 Catania, Italy.
Grazia ScuderiDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.
Giuliana GiuntaDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.
Salvatore LeottaDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.ORCID 0000-0002-5465-5155
Giulio Antonio MiloneDivision of Hematology with BMT, Istituto Oncologico del Mediterraneo, 95029 Viagrande, Italy.
Giulia GiuffridaDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.
Giuseppe Alberto PalumboDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.ORCID 0000-0003-1859-6319
Giuseppe MiloneDivision of Hematology with BMT, A.O.U. Policlinico "G.Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.ORCID 0000-0002-7840-4414
Policlinico Universitario di Catania · ITIstituto Superiore di Sanità · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruxolitinib is a JAK1/2 inhibitor that has revolutionized the approach to myelofibrosis. On the one side, this drug can rapidly improve the symptoms related to the hematological disease; on the other side, the inhibition of JAK1/2 can lead to immunosuppression which may increase the risk of infections, due to a change in the cytokine balance in favor of anti-inflammatory cytokines, to direct inhibition of immune cells, and to the suppression in the production of specific antibodies. In this patient setting, much is known about possible viral and bacterial infections, while little is reported in the literature concerning parasitic infections, specifically leishmaniasis.

Indexed as

cytokinesimmune responseLeishmaniamyelofibrosisruxolitinib

Identifiers

PMID36675507
PMCPMC9866708
OpenAlexW4315647276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.