Evidence map›Paper›PMID 36675258›Full record

ArticleInternational journal of molecular sciences2023

Activity and Crystal Structure of the Adherent-Invasive

Thi Thu Hang Le, Christine Kellenberger, Marie Boyer, Pierre Santucci, Nicolas Flaugnatti, Eric Cascales, Alain Roussel, Stéphane Canaan, Laure Journet, Christian Cambillau

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Tldi1 deficiency mediates Tlde1 self-toxic effect to regulate the adaptability ofFrontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Thi Thu Hang LeArchitecture et Fonction des Macromolécules Biologiques, Aix Marseille University and CNRS, 13288 Marseille, France.
Christine KellenbergerArchitecture et Fonction des Macromolécules Biologiques, Aix Marseille University and CNRS, 13288 Marseille, France.
Marie BoyerLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.
Pierre SantucciLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.
Nicolas FlaugnattiLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.
Eric CascalesLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.ORCID 0000-0003-0611-9179
Alain RousselArchitecture et Fonction des Macromolécules Biologiques, Aix Marseille University and CNRS, 13288 Marseille, France.
Stéphane CanaanLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.ORCID 0000-0001-7478-300X
Laure JournetLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie, Bioénergies et Biotechnologie, Aix Marseille University and CNRS, 13009 Marseille, France.ORCID 0000-0002-5847-2962
Christian CambillauArchitecture et Fonction des Macromolécules Biologiques, Aix Marseille University and CNRS, 13288 Marseille, France.ORCID 0000-0001-5502-4729
Centre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-18-CE15-0013
6 · The paper itself

Abstract

The type VI secretion system (T6SS) delivers enzymatic effectors into target cells to destroy them. Cells of the same strain protect themselves against effectors with immunity proteins that specifically inhibit effectors. Here, we report the identification and characterization of a Tle3 phospholipase effector and its cognate immunity protein Tli3-an outer membrane lipoprotein from adherent-invasive

Indexed as

Escherichia coli InfectionsType VI Secretion SystemsBacterial AdhesionBacterial ProteinsCo-Repressor ProteinsEscherichia coliHumansBacterial ProteinsCo-Repressor ProteinsTLE3 protein, humanType VI Secretion Systemsadherent-invasive Escherichia coli (AIEC)AlphaFold2immunityphospholipaseprotein secretiontype VI secretion systemX-ray structure

Identifiers

PMID36675258
PMCPMC9860674
OpenAlexW4316465013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.