Evidence map›Paper›PMID 36675198›Full record

ArticleInternational journal of molecular sciences2023

A Single Nucleotide Polymorphism rs1010816 Predicts Sorafenib Therapeutic Outcomes in Advanced Hepatocellular Carcinoma.

Chih-Lang Lin, Kung-Hao Liang, Ching-Chih Hu, Cheng-Hung Chien, Li-Wei Chen, Rong-Nan Chien, Yang-Hsiang Lin, Chau-Ting Yeh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chih-Lang LinLiver Research Unit, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Kung-Hao LiangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.ORCID 0000-0002-7593-5965
Ching-Chih HuLiver Research Unit, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Cheng-Hung ChienLiver Research Unit, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Li-Wei ChenLiver Research Unit, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.ORCID 0000-0001-8805-2275
Rong-Nan ChienLiver Research Unit, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Yang-Hsiang LinLiver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.ORCID 0000-0003-4295-6062
Chau-Ting YehLiver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

Chang Gung Memorial Hospital, Taiwan CLRPG2L0052Chang Gung Memorial Hospital, Taiwan CMRPG2J0011Chang Gung Memorial Hospital, Taiwan CMRPG2K0083Chang Gung Memorial Hospital, Taiwan CRRPG2H0045Chang Gung Memorial Hospital, Taiwan NRRPG2L0011
6 · The paper itself

Abstract

Sorafenib is currently a targeted agent widely used in the treatment of advanced hepatocellular carcinoma (aHCC). However, to date there is still a lack of a reliable marker capable of predicting sorafenib therapeutic responses. Here, we conducted a genome-wide association study (GWAS) to identify candidate single-nucleotide polymorphism outcome predictors in aHCC patients. A total of 74 real-world sorafenib-treated aHCC patients were enrolled for GWAS and outcome analysis. GWAS showed that rs1010816 (

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularLiver NeoplasmsGenome-Wide Association StudyHumansNiacinamidePhenylurea CompoundsPolymorphism, Single NucleotideRetrospective StudiesSorafenibTreatment OutcomeAntineoplastic AgentsNiacinamidePhenylurea CompoundsSorafenibadvanced hepatocellular carcinoma (aHCC)genome-wide association study (GWAS)overall survival (OS)

Identifiers

PMID36675198
PMCPMC9862766
OpenAlexW4316371656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.