Evidence map›Paper›PMID 36675151›Full record

ArticleInternational journal of molecular sciences2023

Gut Microbial Perturbation and Host Response Induce Redox Pathway Upregulation along the Gut-Liver Axis during Giardiasis in C57BL/6J Mouse Model.

Avinash V Karpe, Melanie L Hutton, Steven J Mileto, Meagan L James, Chris Evans, Amol B Ghodke, Rohan M Shah, Suzanne S Metcalfe, Jian-Wei Liu, Tom Walsh and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
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  7. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Avinash V KarpeEnvironment, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.ORCID 0000-0002-3731-9598
Melanie L HuttonInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0001-6470-2288
Steven J MiletoInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0003-2599-8957
Meagan L JamesInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0002-3280-7955
Chris EvansInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.
Amol B GhodkeHealth and Biosecurity, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.
Rohan M ShahEnvironment, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.ORCID 0000-0003-4796-0394
Suzanne S MetcalfeEnvironment, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.
Jian-Wei LiuEnvironment, Commonwealth Scientific and Industrial Research Organization, Agricultural and Environmental Sciences Precinct, Acton, Canberra, ACT 2601, Australia.
Tom WalshEnvironment, Commonwealth Scientific and Industrial Research Organization, Agricultural and Environmental Sciences Precinct, Acton, Canberra, ACT 2601, Australia.
Dena LyrasInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.
Enzo A PalomboDepartment of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.ORCID 0000-0001-5889-1393
David J BealeEnvironment, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.ORCID 0000-0002-9948-9197
Australian Regenerative Medicine Institute · AUHealth Sciences and Nutrition · AUSwinburne University of Technology · AUThe University of Queensland · AU

Funding

Commonwealth Scientific and Industrial Research Organisation Probing Biosystems Future Science Platform (FSP)
6 · The paper itself

Abstract

Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mechanisms of disease, particularly the effect on the body beyond the gastrointestinal tract, are still poorly understood. To highlight host-parasite-microbiome biochemical interactions, we utilised integrated metabolomics-16S rRNA genomics and metabolomics-proteomics approaches in a C57BL/6J mouse model of giardiasis and compared these to

Indexed as

CryptosporidiosisCryptosporidiumGastrointestinal MicrobiomeGiardiasisMicrobiotaAnimalsHumansLiverMetabolomeMetabolomicsMiceMice, Inbred C57BLOxidation-ReductionProteomeRNA, Ribosomal, 16SUp-RegulationProteomeRNA, Ribosomal, 16Sgiardiasisgut–liver axishost–parasite interactionsintegrated multiomicsmetabolic pathwayssystems biology

Identifiers

PMID36675151
PMCPMC9862352
OpenAlexW4316371759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.