Evidence map›Paper›PMID 36675101›Full record

ArticleInternational journal of molecular sciences2023

Ginseng Sprouts Attenuate Mortality and Systemic Inflammation by Modulating TLR4/NF-κB Signaling in an LPS-Induced Mouse Model of Sepsis.

Seung-Ju Hwang, Jing-Hua Wang, Jin-Seok Lee, Ji-Yun Kang, Dong-Cheol Baek, Geon-Ho Kim, Yo-Chan Ahn, Chang-Gue Son

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Seung-Ju HwangLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.ORCID 0000-0003-1037-9133
Jing-Hua WangLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.ORCID 0000-0002-2034-7429
Jin-Seok LeeLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.
Ji-Yun KangLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.ORCID 0000-0001-5272-0761
Dong-Cheol BaekLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.ORCID 0000-0003-4523-8920
Geon-Ho KimDepartment of Korean Medicine, Korean Medical College of Daejeon University, Daehak-ro 62, Dong-gu, Daejeon 34520, Republic of Korea.
Yo-Chan AhnDepartment of Health Service Management, Daejeon University, Daehak-ro 62, Dong-gu, Daejeon 34520, Republic of Korea.
Chang-Gue SonLiver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daedukdae-ro 176 bun-gil 75, Seo-gu, Daejeon 35235, Republic of Korea.ORCID 0000-0002-6963-5229
Daejeon University · KR

Funding

National Research Foundation of Korea NRF-2018R1A6A1A03025221
6 · The paper itself

Abstract

Sepsis leads to multi-organ failure due to aggressive systemic inflammation, which is one of the main causes of death clinically. This study aimed to evaluate whether ginseng sprout extracts (GSE) can rescue sepsis and explore its underlying mechanisms. C57BL/6J male mice (

Indexed as

NF-kappa BPanaxPlant ExtractsSepsisAnimalsCyclooxygenase 2InflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLNitric Oxide Synthase Type IIPhytotherapySeedlingsToll-Like Receptor 4Tumor Necrosis Factor-alphaCyclooxygenase 2LipopolysaccharidesNF-kappa BNitric Oxide Synthase Type IIPlant ExtractsTlr4 protein, mouseToll-Like Receptor 4Tumor Necrosis Factor-alphaginseng sproutginsenoside Rdinflammationmulti-organ failuresepsisTLR4/NF-κB pathway

Identifiers

PMID36675101
PMCPMC9860726
OpenAlexW4316041197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.