Evidence map›Paper›PMID 36675091›Full record

ArticleInternational journal of molecular sciences2023

CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.

Ye Liu, Di Wu, Qiuli Fu, Shengjie Hao, Yuzhou Gu, Wei Zhao, Shuying Chen, Feiyin Sheng, Yili Xu, Zhiqing Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

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  20. Involvement ofBiomedicines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ye LiuZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Di WuZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Qiuli FuZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Shengjie HaoZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Yuzhou GuZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Wei ZhaoZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Shuying ChenZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Feiyin ShengZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Yili XuZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Zhiqing ChenZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Ke YaoZhejiang Provincial Key Lab of Ophthalmology, Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.ORCID 0000-0002-6764-7365
Second Affiliated Hospital of Zhejiang University · CN

Funding

Zhejiang Provincial Natural Science Foundation of China 491020+N2211FZJ to Ye Liu and Y23H120038 to Zhiqing Chen
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly population. With aging and the accumulated effects of environmental stress, retinal pigment epithelial (RPE) cells are particularly susceptible to oxidative damage, which can lead to retinal degeneration. However, the underlying molecular mechanisms of how RPE responds and progresses under oxidative damage are still largely unknown. Here, we reveal that exogenous oxidative stress led to ferroptosis characterized by Fe

Indexed as

FerroptosisMacular DegenerationOxidative StressRetinal Pigment EpitheliumAgedEpithelial Cellsgamma-GlutamylcyclotransferaseGlutathioneHumansRetinal PigmentsCHAC1 protein, humangamma-GlutamylcyclotransferaseGlutathioneRetinal Pigmentsage-related macular degeneration (AMD)Chac1ferroptosisoxidative stressretinal pigment epithelial (RPE)

Identifiers

PMID36675091
PMCPMC9861460
OpenAlexW4315853223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.