Evidence map›Paper›PMID 36675037›Full record

ReviewInternational journal of molecular sciences2023

Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers.

Nicole Chizara Oparaugo, Kelsey Ouyang, Nam Phuong N Nguyen, Amanda M Nelson, George W Agak

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
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  7. Article
  8. FOXP3+ T Cells-An Emerging Evidence in Periodontitis Therapeutics.Clinical and experimental dental research · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. The role of exosomes in bladder cancer immunotherapy.Journal of the National Cancer Center · 2025
    Review
  14. Review
  15. Review
  16. Treatment Advances in Vitiligo: An Updated Review.Dermatology practical & conceptual · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nicole Chizara OparaugoDavid Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Kelsey OuyangCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Nam Phuong N NguyenMorsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.
Amanda M NelsonDepartment of Dermatology, Penn State University College of Medicine, Hershey, PA 17033, USA.
George W AgakDivision of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-3356-9864
University of California, Los Angeles · USCleveland Clinic Lerner College of Medicine · USPennsylvania State University · USUniversity of South Florida · US

Funding

The Role of T cell Extracellular Traps in Acne PathogenesisR01AR081337 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI George W Agak · 2022 to 2026
$2.2M
The nature of Propionibacterium acnes-induced inflammatory immune responses in acne vulgarisK01AR071479 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGAK, GEORGE W · 2017 to 2022
$958k
NIAMS NIH HHS K01 AR071479NIAMS NIH HHS NIH K01AR071479NIAMS NIH HHS R01 AR081337NIAMS NIH HHS R01AR081337
6 · The paper itself

Abstract

Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and homeostasis by modulating how the immune system is activated. Several studies have documented the critical role of Tregs in suppressing the functions of effector T cells and antigen-presenting cells. Under certain conditions, Tregs can lose their suppressive capability, leading to a compromised immune system. For example, mutations in the Treg transcription factor,

Indexed as

Autoimmune DiseasesSkin DiseasesSkin NeoplasmsAutoimmunityForkhead Transcription FactorsHumansT-Lymphocytes, RegulatoryForkhead Transcription Factorsautoimmunitycancerhomeostasisimmune suppressioninflammationskinT effector cellstransplantationT-regulatory cells

Identifiers

PMID36675037
PMCPMC9864298
OpenAlexW4316040313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.