Evidence map›Paper›PMID 36674990›Full record

ArticleInternational journal of molecular sciences2023

Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGF

Elena Andreucci, Kelly Bugatti, Silvia Peppicelli, Jessica Ruzzolini, Matteo Lulli, Lido Calorini, Lucia Battistini, Franca Zanardi, Andrea Sartori, Francesca Bianchini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elena AndreucciDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.ORCID 0000-0003-3980-3073
Kelly BugattiDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.
Silvia PeppicelliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.ORCID 0000-0001-6459-0458
Jessica RuzzoliniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Matteo LulliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.ORCID 0000-0002-8528-4094
Lido CaloriniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.ORCID 0000-0002-5508-4200
Lucia BattistiniDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.ORCID 0000-0002-5341-5547
Franca ZanardiDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.ORCID 0000-0001-7451-781X
Andrea SartoriDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.ORCID 0000-0002-9688-6760
Francesca BianchiniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.ORCID 0000-0002-5839-4298
University of Florence · ITUniversity of Parma · IT

Funding

Ente Cassa di Risparmio di Firenze BIANCRF181014Italian Ministry of Education, University and Research Protocol n. 2020833Y75_003Italian Ministry of Education, University and Research RICATEN2020/2021
6 · The paper itself

Abstract

Growth factors and cytokines released in the lung cancer microenvironment promote an epithelial-to-mesenchymal transition (EMT) that sustains the progression of neoplastic diseases. TGF

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsAntigens, NeoplasmCell Line, TumorEpithelial-Mesenchymal TransitionHumansIndolesIntegrinsLigandsTransforming Growth Factor betaTumor MicroenvironmentAntigens, NeoplasmAntineoplastic AgentsIndolesintegrin alphavbeta6IntegrinsLigandsnintedanibTransforming Growth Factor betaA549 lung cancer cellsepithelial-mesenchymal transition (EMT)molecular conjugatesnintedanibtransforming growth factorβ (TGFβ)αvβ6 integrin ligands

Identifiers

PMID36674990
PMCPMC9861180
OpenAlexW4315640537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.