Evidence map›Paper›PMID 36674983›Full record

ArticleInternational journal of molecular sciences2023

Enhanced Cytotoxic Activity of PEGylated Curcumin Derivatives: Synthesis, Structure-Activity Evaluation, and Biological Activity.

Dawid Lazewski, Malgorzata Kucinska, Edward Potapskiy, Joanna Kuzminska, Lukasz Popenda, Artur Tezyk, Tomasz Goslinski, Marcin Wierzchowski, Marek Murias

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dawid LazewskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0002-9832-5094
Malgorzata KucinskaDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631 Poznan, Poland.ORCID 0000-0002-3606-3623
Edward PotapskiyDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland.
Joanna KuzminskaDepartment of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0002-8514-5238
Lukasz PopendaNanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3 Street, 61-614 Poznan, Poland.ORCID 0000-0003-1117-3081
Artur TezykDepartment of Forensic Medicine, Poznan University of Medical Sciences, Rokietnicka 10 Street, 60-806 Poznan, Poland.
Tomasz GoslinskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0001-5705-5414
Marcin WierzchowskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland.
Marek MuriasDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631 Poznan, Poland.ORCID 0000-0002-2903-4912
Poznan University of Medical Sciences · PLAdam Mickiewicz University in Poznań · PL

Funding

National Science Center 2019/35/B/NZ7/01165
6 · The paper itself

Abstract

Curcumin has been modified in various ways to broaden its application in medicine and address its limitations. In this study, we present a series of curcumin-based derivatives obtained by replacing the hydroxy groups in the feruloyl moiety with polyethylene glycol (PEG) chains and the addition of the BF

Indexed as

Antineoplastic AgentsCurcuminUrinary Bladder NeoplasmsApoptosisCell Line, TumorG2 Phase Cell Cycle CheckpointsHumansStructure-Activity RelationshipAntineoplastic AgentsCurcuminbladder cancercurcumincurcumin derivativeshypoxiaPEGylation

Identifiers

PMID36674983
PMCPMC9867315
OpenAlexW4315796926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.