Evidence map›Paper›PMID 36674945›Full record

ArticleInternational journal of molecular sciences2023

α-Synuclein Induces Neuroinflammation Injury through the

Danyu Lin, Han Zhang, Jieli Zhang, Kaixun Huang, Ying Chen, Xiuna Jing, Enxiang Tao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. COL8A1 regulates endothelial phenotype in inflammatory endothelial-to-mesenchymal transition.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  11. Review
  12. Decoding the therapeutic potential mechanism ofFrontiers in pharmacology · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Retinal glia in myopia: current understanding and future directions.Frontiers in cell and developmental biology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danyu LinDepartment of Neurology, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Han ZhangDepartment of Neurology, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Jieli ZhangDepartment of Neurology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, China.
Kaixun HuangDepartment of Neurology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, China.
Ying ChenDepartment of Neurology, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510080, China.ORCID 0000-0001-5379-675X
Xiuna JingDepartment of Neurology, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Enxiang TaoDepartment of Neurology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, China.ORCID 0000-0001-6527-4967
Sun Yat-sen University · CN

Funding

Basic Research of Shenzhen Science and Technology Project, China JCYJ20210324115008022, JCYJ20220530144211024Guangzhou Science and Technology Research Project, China 2018B030337001Health Public Welfare Scientific Research Projects of Futian, China FTWS2021069National Natural Science Foundation of China 82271454, 81971195
6 · The paper itself

Abstract

The aggregation of α-synuclein (α-syn) promotes neuroinflammation and neuronal apoptosis, which eventually contribute to the pathogenesis of Parkinson's disease (PD). Our microarray analysis and experimental data indicated a significant expression difference of the long noncoding RNA

Indexed as

NeuroblastomaParkinson Diseasealpha-SynucleinCytokine Receptor gp130HumansInterleukin-6MicrogliaNeuroinflammatory DiseasesSTAT3 Transcription Factoralpha-SynucleinCytokine Receptor gp130IL6ST protein, humanInterleukin-6STAT3 protein, humanSTAT3 Transcription FactorIL6ST-AS/STAT3/HIF-1α axisneuroinflammationParkinson’s diseaseα-synuclein

Identifiers

PMID36674945
PMCPMC9861378
OpenAlexW4315574552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.