Evidence map›Paper›PMID 36674883›Full record

ArticleInternational journal of molecular sciences2023

Folic-Acid-Conjugated Thermoresponsive Polymeric Particles for Targeted Delivery of 5-Fluorouracil to CRC Cells.

Sylwia Milewska, Gabriela Siemiaszko, Agnieszka Zofia Wilczewska, Iwona Misztalewska-Turkowicz, Karolina Halina Markiewicz, Dawid Szymczuk, Diana Sawicka, Halina Car, Ryszard Lazny, Katarzyna Niemirowicz-Laskowska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sylwia MilewskaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.ORCID 0000-0002-6362-8132
Gabriela SiemiaszkoFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.
Agnieszka Zofia WilczewskaFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.ORCID 0000-0001-8587-6711
Iwona Misztalewska-TurkowiczFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.ORCID 0000-0001-6191-6053
Karolina Halina MarkiewiczFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.ORCID 0000-0002-4857-0489
Dawid SzymczukFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.ORCID 0000-0002-8225-3196
Diana SawickaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.ORCID 0000-0002-6804-3459
Halina CarDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.
Ryszard LaznyFaculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland.
Katarzyna Niemirowicz-LaskowskaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.ORCID 0000-0002-3311-7147
University of Białystok · PLMedical University of Białystok · PL

Funding

National Science Center NCN/2016/21/B/ST5/01365
6 · The paper itself

Abstract

Colorectal cancer is the fourth most common cancer worldwide and the third most frequently diagnosed form of cancer associated with high mortality rates. Recently, targeted drug delivery systems have been under increasing attention owing to advantages such as high therapeutic effectiveness with a significant depletion in adverse events. In this report, we describe the biocompatible and thermoresponsive FA-conjugated PHEA-

Indexed as

Colorectal NeoplasmsNanoparticlesDrug CarriersDrug Delivery SystemsFluorouracilFolic AcidHumansPolymersQuality of LifeSpectroscopy, Fourier Transform InfraredDrug CarriersFluorouracilFolic AcidPolymers5-fluorouracilcolorectal cancerdrug delivery systemsfolate receptorsfolic acidmitigatorNIPAAmPHEA-b-PNIPAAmPNIPAAmpolymeric carriersRAFT polymerizationtargeted deliverythermoresponsive polymer

Identifiers

PMID36674883
PMCPMC9861804
OpenAlexW4315649429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.