Evidence map›Paper›PMID 36674863›Full record

ArticleInternational journal of molecular sciences2023

2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection-Exploring the Role of the Red Blood Cell Membrane.

Maria Carvalho, Márcia M Medeiros, Inês Morais, Catarina S Lopes, Ana Balau, Nuno C Santos, Filomena A Carvalho, Ana Paula Arez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Maria CarvalhoGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisbon, Portugal.ORCID 0000-0001-8049-8280
Márcia M MedeirosGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisbon, Portugal.
Inês MoraisGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisbon, Portugal.
Catarina S LopesInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.ORCID 0000-0001-8561-4527
Ana BalauGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisbon, Portugal.
Nuno C SantosInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.ORCID 0000-0002-0580-0475
Filomena A CarvalhoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.ORCID 0000-0001-6088-3894
Ana Paula ArezGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisbon, Portugal.ORCID 0000-0002-0497-6532
University of Lisbon · PT

Funding

Fundação para a Ciência e Tecnologia GHTM - UID/04413/2020Fundação para a Ciência e Tecnologia PD/BD/135045/2017Fundação para a Ciência e Tecnologia PTDC_BIA-CEL_28456_2017
6 · The paper itself

Abstract

Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, and understanding the protective mechanisms involved may be useful for developing host-directed tools to control

Indexed as

MalariaMalaria, Falciparum2,3-DiphosphoglycerateAnemia, Hemolytic, Congenital NonspherocyticDiphosphoglyceric AcidsErythrocytesHumansPlasmodium falciparumPyruvate KinasePyruvate Metabolism, Inborn Errors2,3-DiphosphoglycerateDiphosphoglyceric AcidsPyruvate Kinase2,3-diphosphoglycerateerythrocytemalariamembrane propertiesmorphologyred blood cell

Identifiers

PMID36674863
PMCPMC9866842
OpenAlexW4315498613

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.